Dataset Information

Aerobic exercise and telomere length in patients with systolic heart failure: protocol study for a randomized controlled trial.

ABSTRACT:

Background

Heart failure (HF) with reduced ejection fraction (HFrEF) is a syndrome that leads to fatigue and reduced functional capacity due to disease-related pathophysiological mechanisms. Aerobic exercise (AERO) plays a key role in improving HF outcomes, such as an increase in peak oxygen uptake (VO₂peak). In addition, HF promotes cell senescence, which involves reducing telomere length. Several studies have shown that patients with a worse prognosis (i.e., reduced VO₂ peak) also have shorter telomeres. However, the effects of AERO on telomere length in patients with HFrEF are still unknown. In an attempt to fill this gap, we designed a study to determine the effects of 16 weeks of aerobic training (32 sessions) on telomere length in HFrEF patients.

Methods

In this single-center randomized controlled trial, men and women between 50 and 80 years old will be allocated into two different groups: a moderate-intensity aerobic training and a control grouTelomere length, functional capacity, echocardiographic variables, endothelial function, and walking ability will be assessed before and after the 16-week intervention period.

Discussion

Understanding the role of physical exercise in biological aging in HFrEF patients is relevant. Due to cell senescence, these individuals have shown a shorter telomere length. AERO can delay biological aging according to a balance in oxidative stress through antioxidant action. Positive telomere length results are expected for the aerobic training group.

Trial registration

ClinicalTrials.gov NCT03856736 . Registered on February 27, 2019.

SUBMITTER: Franzoni LT

PROVIDER: S-EPMC8996601 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Aerobic exercise and telomere length in patients with systolic heart failure: protocol study for a randomized controlled trial.

Franzoni Leandro T LT Garcia Eduardo L EL Motta Stephanie B SB Ahner Mabel M MM Bertoletti Otávio A OA Saffi Marco A L MAL da Silveira Anderson D AD Pereira Alexandre A AA Pereira Adamastor H AH Danzmann Luiz C LC Stein Ricardo R

Trials 20220411 1

<h4>Background</h4>Heart failure (HF) with reduced ejection fraction (HFrEF) is a syndrome that leads to fatigue and reduced functional capacity due to disease-related pathophysiological mechanisms. Aerobic exercise (AERO) plays a key role in improving HF outcomes, such as an increase in peak oxygen uptake (VO<sub>2</sub>peak). In addition, HF promotes cell senescence, which involves reducing telomere length. Several studies have shown that patients with a worse prognosis (i.e., reduced VO<sub>2 ...[more]

PMID: 35410445

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Dataset Information

Aerobic exercise and telomere length in patients with systolic heart failure: protocol study for a randomized controlled trial.

Background

Methods

Discussion

Trial registration

Publications

Aerobic exercise and telomere length in patients with systolic heart failure: protocol study for a randomized controlled trial.

Similar Datasets

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