Dataset Information

Neuroprotective effects of strength training in a neuroinflammatory animal model.

ABSTRACT:

Background

The preventive role of muscular strength on diminishing neuroinflammation is yet unknown. In this study, the role of the prophylactic muscular strength exercise was investigated in order to verify whether it would diminish cognitive alterations and modify the antioxidant intracellular scenery in an animal neuroinflammatory model in of the CA1 region of the hippocampus.

Methods

The animals received muscular strength training (SE) three times a week for eight weeks. Subsequently, the stereotaxic surgery was performed with an intra-hippocampal infusion of either saline solution (SAL) or lipopolysaccharide (LPS). Next, we performed the behavioral tests: object recognition and social recognition. Then, the animals were euthanized, and their hippocampus and prefrontal cortex were collected. In another moment, we performed the dosage of the antioxidant activity and histological analysis.

Results

The results showed that the muscular strength exercises could show a beneficial prophylactic effect in the cognitive deficiencies caused by acute neuroinflammation. Regarding oxidative stress, there was an increase in catalase enzyme activity (CAT) in the group (SE + LPS) compared to the control groups (p < 0.05). As for the cognitive alterations, there were found in the (SE + LPS) group, diminishing the mnemonic hazard of the discriminative and social memories compared to the control groups (p < 0.05).

Conclusion

We concluded, therefore, that the exercise performed prophylactically presents a protective effect capable of minimizing such mnemonic deficits and increasing catalase enzyme activity in rats that suffered a local neuroinflammatory process in the hippocampus.

SUBMITTER: de Gregorio E

PROVIDER: S-EPMC8996658 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Publications

Neuroprotective effects of strength training in a neuroinflammatory animal model.

de Gregório Elizama E Mendes Gabriela Cristiane GC Somensi Lincon Bordignon LB Freire Cassio Geremia CG Lopes Luiza Freitas LF Lima Karine Ramires KR Carrazoni Guilherme Salgado GS Neves Ben-Hur Souto BS Picua Steffanie Severo SS da Silva Luisa Mota LM Mello-Carpes Pamela Billig PB Bonini Juliana Sartori JS da Silva Weber Claudio WC

BMC neuroscience 20220411 1

<h4>Background</h4>The preventive role of muscular strength on diminishing neuroinflammation is yet unknown. In this study, the role of the prophylactic muscular strength exercise was investigated in order to verify whether it would diminish cognitive alterations and modify the antioxidant intracellular scenery in an animal neuroinflammatory model in of the CA1 region of the hippocampus.<h4>Methods</h4>The animals received muscular strength training (SE) three times a week for eight weeks. Subse ...[more]

PMID: 35410134

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Dataset Information

Neuroprotective effects of strength training in a neuroinflammatory animal model.

Background

Methods

Results

Conclusion

Publications

Neuroprotective effects of strength training in a neuroinflammatory animal model.

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