Mechanism of metronidazole resistance in Helicobacter pylori: comparison of the rdxA gene sequences in 30 strains.
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ABSTRACT:
SUBMITTER: Solca NM
PROVIDER: S-EPMC90043 | biostudies-literature | 2000 Aug
REPOSITORIES: biostudies-literature
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Mechanism of metronidazole resistance in Helicobacter pylori: comparison of the rdxA gene sequences in 30 strains.
Solcà N M NM Bernasconi M V MV Piffaretti J C JC
Antimicrobial agents and chemotherapy 20000801 8
The rdxA gene of 30 independently isolated Helicobacter pylori strains was sequenced. A comparison of the rdxA sequences revealed a higher percentage of amino acid substitutions in the corresponding protein than in other housekeeping genes. Out of 122 point mutations, 41 were missense and 4 were nonsense. A resistant strain with a nucleotide insertion in the rdxA sequence was also found. With the exception of the point mutations and the insertion generating a stop signal, no particular nucleotid ...[more]
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