Ontology highlight
ABSTRACT:
SUBMITTER: Swaney DL
PROVIDER: S-EPMC9005332 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Swaney Danielle L DL Ramms Dana J DJ Wang Zhiyong Z Park Jisoo J Goto Yusuke Y Soucheray Margaret M Bhola Neil N Kim Kyumin K Zheng Fan F Zeng Yan Y McGregor Michael M Herrington Kari A KA O'Keefe Rachel R Jin Nan N VanLandingham Nathan K NK Foussard Helene H Von Dollen John J Bouhaddou Mehdi M Jimenez-Morales David D Obernier Kirsten K Kreisberg Jason F JF Kim Minkyu M Johnson Daniel E DE Jura Natalia N Grandis Jennifer R JR Gutkind J Silvio JS Ideker Trey T Krogan Nevan J NJ
Science (New York, N.Y.) 20211001 6563
We outline a framework for elucidating tumor genetic complexity through multidimensional protein-protein interaction maps and apply it to enhancing our understanding of head and neck squamous cell carcinoma. This network uncovers 771 interactions from cancer and noncancerous cell states, including WT and mutant protein isoforms. Prioritization of cancer-enriched interactions reveals a previously unidentified association of the fibroblast growth factor receptor tyrosine kinase 3 with Daple, a gua ...[more]