Dataset Information

Collagen-coated superparamagnetic iron oxide nanoparticles as a sustainable catalyst for spirooxindole synthesis.

ABSTRACT: In this work, a novel magnetic organic-inorganic hybrid catalyst was fabricated by encapsulating magnetite@silica (Fe₃O₄@SiO₂) nanoparticles with Isinglass protein collagen (IGPC) using epichlorohydrin (ECH) as a crosslinking agent. Characterization studies of the prepared particles were accomplished by various analytical techniques specifically, Fourier transform infrared (FTIR) analysis, scanning electron microscopy (SEM), transmission electron microscopy (TEM), vibrating sample magnetometry (VSM), energy-dispersive X-ray spectroscopy (EDS), X-ray powder diffraction (XRD), thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) analysis. The XRD results showed a crystalline and amorphous phase which contribute to magnetite and isinglass respectively. Moreover, the formation of the core/shell structure had been confirmed by TEM images. The synthesized Fe₃O₄@SiO₂/ECH/IG was applied as a bifunctional heterogeneous catalyst in the synthesis of spirooxindole derivatives through the multicomponent reaction of isatin, malononitrile, and C-H acids which demonstrated its excellent catalytic properties. The advantages of this green approach were low catalyst loading, short reaction time, stability, and recyclability for at least four runs.

SUBMITTER: Azarnier SG

PROVIDER: S-EPMC9005729 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Collagen-coated superparamagnetic iron oxide nanoparticles as a sustainable catalyst for spirooxindole synthesis.

Azarnier Shima Ghanbari SG Esmkhani Maryam M Dolatkhah Zahra Z Javanshir Shahrzad S

Scientific reports 20220412 1

In this work, a novel magnetic organic-inorganic hybrid catalyst was fabricated by encapsulating magnetite@silica (Fe3O4@SiO2) nanoparticles with Isinglass protein collagen (IGPC) using epichlorohydrin (ECH) as a crosslinking agent. Characterization studies of the prepared particles were accomplished by various analytical techniques specifically, Fourier transform infrared (FTIR) analysis, scanning electron microscopy (SEM), transmission electron microscopy (TEM) ...[more]

PMID: 35414646

Similar Datasets

Project description:Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely utilized for the diagnosis and therapy of specific diseases, as magnetic resonance imaging (MRI) contrast agents and drug-delivery carriers, due to their easy transportation to targeted areas by an external magnetic field. For such biomedical applications, SPIONs must have multifunctional characteristics, including optimized size and modified surface. However, the biofunctionality and biocompatibility of SPIONs with various surface functional groups of different sizes have yet to be elucidated clearly. Therefore, it is important to carefully monitor the cytotoxicity and genotoxicity of SPIONs that are surfaced-modified with various functional groups of different sizes. In this study, we evaluated SPIONs with diameters of approximately 10 nm and 100~150 nm, containing different surface functional groups. SPIONs were covered with -O⁻ groups, so-called bare SPIONs. Following this, they were modified with three different functional groups--hydroxyl (-OH), carboxylic (-COOH), and amine (-NH₂) groups--by coating their surfaces with tetraethyl orthosilicate (TEOS), (3-aminopropyl)trimethoxysilane (APTMS), TEOS-APTMS, or citrate, which imparted different surface charges and sizes to the particles. The effects of SPIONs coated with these functional groups on mitochondrial activity, intracellular accumulation of reactive oxygen species, membrane integrity, and DNA stability in L-929 fibroblasts were determined by water-soluble tetrazolium, 2',7'-dichlorodihydrofluorescein, lactate dehydrogenase, and comet assays, respectively. Our toxicological observations suggest that the functional groups and sizes of SPIONs are critical determinants of cellular responses, degrees of cytotoxicity and genotoxicity, and potential mechanisms of toxicity. Nanoparticles with various surface modifications and of different sizes induced slight, but possibly meaningful, changes in cell cytotoxicity and genotoxicity, which would be significantly valuable in further studies of bioconjugation and cell interaction for drug delivery, cell culture, and cancer-targeting applications.

Dataset Information

Collagen-coated superparamagnetic iron oxide nanoparticles as a sustainable catalyst for spirooxindole synthesis.

Publications

Collagen-coated superparamagnetic iron oxide nanoparticles as a sustainable catalyst for spirooxindole synthesis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets