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Evaluation of rapid antigen detection kits for detection of SARS-CoV-2 B.1.617.2 virus.


ABSTRACT: Aim: Currently, there is lack of data regarding rapid antigen detection (RAD) kits to detect SARS-CoV-2 B.1.617.2 virus. Objective: The purpose of this evaluation is to assess analytical sensitivity of 12 RAD kits against SARS-CoV-2 B.1.617.2. Study design: Analytical sensitivity was determined by limit of detection (LOD). A serial tenfold dilution set from a respiratory specimen collected from a COVID-19 patient infected by SARS-CoV-2 B.1.617.2 was used. RT-PCR was used as a reference method. Results: The LOD results showed that 11 and one RAD kits were 100- and 1000-fold less sensitive than RT-PCR respectively. Conclusion: The results showed that the RAD kits evaluated in this study may be used for first-line screening of the SARS-CoV-2 B.1.617.2 variant.

SUBMITTER: Mak GC 

PROVIDER: S-EPMC9006337 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Evaluation of rapid antigen detection kits for detection of SARS-CoV-2 B.1.617.2 virus.

Mak Gannon Ck GC   Lau Stephen Sy SS   Wong Kitty Ky KK   Chow Nancy Ls NL   Lau Chi-Shan CS   Lam Edman Tk ET   Ng Ken Hl KH   Chan Rickjason Cw RC  

Future virology 20220301


<b>Aim:</b> Currently, there is lack of data regarding rapid antigen detection (RAD) kits to detect SARS-CoV-2 B.1.617.2 virus. <b>Objective:</b> The purpose of this evaluation is to assess analytical sensitivity of 12 RAD kits against SARS-CoV-2 B.1.617.2. <b>Study design:</b> Analytical sensitivity was determined by limit of detection (LOD). A serial tenfold dilution set from a respiratory specimen collected from a COVID-19 patient infected by SARS-CoV-2 B.1.617.2 was used. RT-PCR was used as  ...[more]

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