Ontology highlight
ABSTRACT:
SUBMITTER: Wu Y
PROVIDER: S-EPMC9009132 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Wu Yingga Y Green Cara L CL Wang Guanlin G Yang Dengbao D Li Li L Li Baoguo B Wang Lu L Li Min M Li Jianbo J Xu Yanchao Y Zhang Xueying X Niu Chaoqun C Hu Sumei S Togo Jacques J Mazidi Mohsen M Derous Davina D Douglas Alex A Speakman John R JR
Aging cell 20220310 4
Dietary macronutrient composition influences both hepatic function and aging. Previous work suggested that longevity and hepatic gene expression levels were highly responsive to dietary protein, but almost unaffected by other macronutrients. In contrast, we found expression of 4005, 4232, and 4292 genes in the livers of mice were significantly associated with changes in dietary protein (5%-30%), fat (20%-60%), and carbohydrate (10%-75%), respectively. More genes in aging-related pathways (notabl ...[more]