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Common idiopathic pulmonary fibrosis risk variants are associated with hypersensitivity pneumonitis.


ABSTRACT: A subset of patients with hypersensitivity pneumonitis (HP) develop lung fibrosis that is clinically similar to idiopathic pulmonary fibrosis (IPF). To address the aetiological determinants of fibrotic HP, we investigated whether the common IPF genetic risk variants were also relevant in study subjects with fibrotic HP. Our findings indicate that common genetic variants in TERC, DSP, MUC5B and IVD were significantly associated with fibrotic HP. These findings provide support for a shared etiology and pathogenesis between fibrotic HP and IPF.

SUBMITTER: Furusawa H 

PROVIDER: S-EPMC9013199 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Common idiopathic pulmonary fibrosis risk variants are associated with hypersensitivity pneumonitis.

Furusawa Haruhiko H   Peljto Anna L AL   Walts Avram D AD   Cardwell Jonathan J   Molyneaux Philip L PL   Lee Joyce S JS   Fernández Pérez Evans R ER   Wolters Paul J PJ   Yang Ivana V IV   Schwartz David A DA  

Thorax 20220107 5


A subset of patients with hypersensitivity pneumonitis (HP) develop lung fibrosis that is clinically similar to idiopathic pulmonary fibrosis (IPF). To address the aetiological determinants of fibrotic HP, we investigated whether the common IPF genetic risk variants were also relevant in study subjects with fibrotic HP. Our findings indicate that common genetic variants in <i>TERC</i>, <i>DSP</i>, <i>MUC5B</i> and <i>IVD</i> were significantly associated with fibrotic HP. These findings provide  ...[more]

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