Dataset Information

Normalisation of airflow limitation in asthma: Post-hoc analyses of TRIMARAN and TRIGGER.

ABSTRACT:

Background

In asthma, persistent airflow limitation (PAL) is associated with poorer control, lung function decline and exacerbations. Using post-hoc analyses we evaluated: the relationship between post-salbutamol PAL at screening, airflow limitation (AL) during 52 weeks treatment with extrafine beclometasone dipropionate/formoterol fumarate/glycopyrronium (BDP/FF/G) versus BDP/FF and the risk of moderate/severe asthma exacerbations.

Methods

TRIMARAN and TRIGGER were double-blind studies comparing BDP/FF/G with BDP/FF (TRIMARAN medium-dose ICS; TRIGGER high-dose) in adults with uncontrolled asthma. Patients were subgrouped according to post-salbutamol PAL status at screening, and AL over the 52-week treatment period.

Results

Most patients with post-salbutamol PAL at screening had AL at all on-treatment visits (TRIMARAN 62.8%; TRIGGER 66.8%). A significantly higher proportion of patients had normalised airflow on ≥1 follow-up visit when receiving BDP/FF/G than BDP/FF (TRIMARAN 44.1 vs. 33.1% [p = 0.003]; TRIGGER 40.1 vs. 26.0% [p < 0.001]). In patients with post-salbutamol PAL at screening and normalised AL at ≥1 follow-up visit, exacerbation rates were 15% (p = 0.105) and 19% (p = 0.039) lower in TRIMARAN and TRIGGER versus those with AL on all visits. There was a trend to lower exacerbation rates in patients receiving BDP/FF/G than BDP/FF, particularly in patients in whom AL was normalised.

Conclusion

In these analyses, AL in asthma was associated with an increased exacerbation incidence. Inhaled triple therapy with extrafine BDP/FF/G was more likely to normalise airflow, and was associated with a trend to a lower exacerbation rate than BDP/FF, particularly in the subgroup of patients in whom treatment was associated with airflow normalisation.ClinicalTrials.gov: TRIMARAN, NCT02676076; TRIGGER, NCT02676089.

SUBMITTER: Papi A

PROVIDER: S-EPMC9014197 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Publications

Normalisation of airflow limitation in asthma: Post-hoc analyses of TRIMARAN and TRIGGER.

Papi Alberto A Singh Dave D Virchow J Christian JC Canonica G Walter GW Vele Andrea A Georges George G

Clinical and translational allergy 20220417 4

<h4>Background</h4>In asthma, persistent airflow limitation (PAL) is associated with poorer control, lung function decline and exacerbations. Using post-hoc analyses we evaluated: the relationship between post-salbutamol PAL at screening, airflow limitation (AL) during 52 weeks treatment with extrafine beclometasone dipropionate/formoterol fumarate/glycopyrronium (BDP/FF/G) versus BDP/FF and the risk of moderate/severe asthma exacerbations.<h4>Methods</h4>TRIMARAN and TRIGGER were double-blind s ...[more]

PMID: 35450196

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Dataset Information

Normalisation of airflow limitation in asthma: Post-hoc analyses of TRIMARAN and TRIGGER.

Background

Methods

Results

Conclusion

Publications

Normalisation of airflow limitation in asthma: Post-hoc analyses of TRIMARAN and TRIGGER.

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