Dataset Information

Do Early-Life Social, Behavioral, and Health Exposures Increase Later-Life Arthritis Incidence?

ABSTRACT:

Objectives

This study investigates direct and indirect influences of childhood social, behavioral, and health exposures on later-life osteoarthritis and rheumatoid arthritis development.

Methods

Drawing from cumulative inequality theory and six waves of the Health and Retirement Study (2004-2014), we estimate structural equation modeling-based discrete-time survival analysis of the association between six childhood exposure domains and both osteoarthritis and rheumatoid arthritis incidence for men (n = 2720) and women (n = 2974). Using the delta method to test for mediation, we examine indirect effects via selected health-related risks and resources.

Results

Risky adolescent behavior is associated with rheumatoid arthritis incidence for women (h.O.R. = 1.883, 95% C.I. [1.016, 3.490]), whereas several types of childhood exposures are associated with later-life osteoarthritis development for both men and women. Experiencing two or more childhood socioeconomic disadvantages is indirectly associated with osteoarthritis (men: coef. = 0.024, 95% C.I. [0.003, 0.045]; women: coef. = 0.111, 95% C.I. [0.071, 0.150]) and rheumatoid arthritis (men: coef. = 0.037, 95% C.I. [0.000, 0.074]; women: coef. = 0.097, 95% C.I. [0.035, 0.159]) development through adult body mass index.

Discussion

Findings highlight the importance of childhood contexts in understanding the development of later-life osteoarthritis and rheumatoid arthritis.

SUBMITTER: Kemp BR

PROVIDER: S-EPMC9016101 | biostudies-literature | 2022 Aug-Sep

REPOSITORIES: biostudies-literature

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Publications

Do Early-Life Social, Behavioral, and Health Exposures Increase Later-Life Arthritis Incidence?

Kemp Blakelee R BR Ferraro Kenneth F KF Morton Patricia M PM Thomas Patricia A PA Mustillo Sarah A SA Crimmins Eileen M EM

Research on aging 20211019 7-8

<h4>Objectives</h4>This study investigates direct and indirect influences of childhood social, behavioral, and health exposures on later-life osteoarthritis and rheumatoid arthritis development.<h4>Methods</h4>Drawing from cumulative inequality theory and six waves of the Health and Retirement Study (2004-2014), we estimate structural equation modeling-based discrete-time survival analysis of the association between six childhood exposure domains and both osteoarthritis and rheumatoid arthritis ...[more]

PMID: 34664538

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Dataset Information

Do Early-Life Social, Behavioral, and Health Exposures Increase Later-Life Arthritis Incidence?

Objectives

Methods

Results

Discussion

Publications

Do Early-Life Social, Behavioral, and Health Exposures Increase Later-Life Arthritis Incidence?

Similar Datasets

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