The current toolbox for APOBEC drug discovery.
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ABSTRACT:
SUBMITTER: Grillo MJ
PROVIDER: S-EPMC9018551 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
The current toolbox for APOBEC drug discovery.
Grillo Michael J MJ Jones Katherine F M KFM Carpenter Michael A MA Harris Reuben S RS Harki Daniel A DA
Trends in pharmacological sciences 20220501 5
Mutational processes driving genome evolution and heterogeneity contribute to immune evasion and therapy resistance in viral infections and cancer. APOBEC3 (A3) enzymes promote such mutations by catalyzing the deamination of cytosines to uracils in single-stranded DNA. Chemical inhibition of A3 enzymes may yield an antimutation therapeutic strategy to improve the durability of current drug therapies that are prone to resistance mutations. A3 small-molecule drug discovery efforts to date have bee ...[more]
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