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Information normally considered task-irrelevant drives decision-making and affects premotor circuit recruitment.


ABSTRACT: Decision-making is a continuous and dynamic process with prior experience reflected in and used by the brain to guide adaptive behavior. However, most neurobiological studies constrain behavior and/or analyses to task-related variables, not accounting for the continuous internal and temporal space in which they occur. We show mice rely on information learned through recent and longer-term experience beyond just prior actions and reward - including checking behavior and the passage of time - to guide self-initiated, self-paced, and self-generated actions. These experiences are represented in secondary motor cortex (M2) activity and its projections into dorsal medial striatum (DMS). M2 integrates this information to bias strategy-level decision-making, and DMS projections reflect specific aspects of this recent experience to guide actions. This suggests diverse aspects of experience drive decision-making and its neural representation, and shows premotor corticostriatal circuits are crucial for using selective aspects of experiential information to guide adaptive behavior.

SUBMITTER: Schreiner DC 

PROVIDER: S-EPMC9018678 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Information normally considered task-irrelevant drives decision-making and affects premotor circuit recruitment.

Schreiner Drew C DC   Cazares Christian C   Renteria Rafael R   Gremel Christina M CM  

Nature communications 20220419 1


Decision-making is a continuous and dynamic process with prior experience reflected in and used by the brain to guide adaptive behavior. However, most neurobiological studies constrain behavior and/or analyses to task-related variables, not accounting for the continuous internal and temporal space in which they occur. We show mice rely on information learned through recent and longer-term experience beyond just prior actions and reward - including checking behavior and the passage of time - to g  ...[more]

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