Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Lopez J
PROVIDER: S-EPMC9022217 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
García-López Jesus J Wallace Kirby K Otero Joel H JH Olsen Rachelle R Wang Yong-Dong YD Finkelstein David D Gudenas Brian L BL Rehg Jerold E JE Northcott Paul P Davidoff Andrew M AM Freeman Kevin W KW
Cell reports 20200101 2
Loss of heterozygosity (LOH) at 1p36 occurs in multiple cancers, including neuroblastoma (NBL). MYCN amplification and 1p36 deletions tightly correlate with markers of tumor aggressiveness in NBL. Although distal 1p36 losses associate with single-copy MYCN tumors, larger deletions correlate with MYCN amplification, indicating two tumor suppressor regions in 1p36, only one of which facilitates MYCN oncogenesis. To better define this region, we genome-edited the syntenic 1p36 locus in primary mous ...[more]