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Lipoprotein Levels in Early Adulthood and NAFLD in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.


ABSTRACT:

Objective

We evaluated the association of apolipoprotein B (apoB) with low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and triglycerides (TG) in early adulthood with concordant/discordant associations and midlife NAFLD.

Methods

Participants from the CARDIA study were included (n = 2,655; baseline mean age: 25.0, 59.1% female, and 48.6% black). NAFLD was defined as liver attenuation ≤40 Hounsfield units after excluding other causes of liver fat. Logistic regression models assessed the odds of Y25 NAFLD among tertiles of apoB, LDL-C, non-HDL-C, and TG and quartiles of the apoB/TG ratio. Discordance/concordance analyses examined the association of apoB with each lipid marker and Y25 NAFLD.

Results

The Y25 NAFLD prevalence was 10%. The high-tertile TG group (OR 1.87, 95% CI, and 1.30-2.69) and the low- (OR 1.98, 95% CI, and 1.30-3.01) and middle-apoB/TG ratio groups (OR 1.78, 95% CI, and 1.17-2.72) had the greatest odds of midlife NAFLD. Using discordance/concordance analysis, the high-apoB/high-TG group had the highest odds of NAFLD (OR 1.69, 95% CI, and 1.09-2.61) followed by the low-apoB/high-TG group. The high apoB/low TG group had the lowest odds of NAFLD.

Conclusions

Among the studied lipid markers in early adulthood, TG levels have the strongest and most consistent association with midlife NAFLD.

SUBMITTER: Khanna S 

PROVIDER: S-EPMC9023214 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Lipoprotein Levels in Early Adulthood and NAFLD in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Khanna Sahil S   Wilkins John T JT   Ning Hongyan H   Allen Norrina B NB   Lewis Cora E CE   Carr J Jeffrey JJ   Lloyd-Jones Donald D   VanWagner Lisa B LB  

Journal of nutrition and metabolism 20220414


<h4>Objective</h4>We evaluated the association of apolipoprotein B (apoB) with low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and triglycerides (TG) in early adulthood with concordant/discordant associations and midlife NAFLD.<h4>Methods</h4>Participants from the CARDIA study were included (<i>n</i> = 2,655; baseline mean age: 25.0, 59.1% female, and 48.6% black). NAFLD was defined as liver attenuation ≤40 Hounsfield units after excluding other  ...[more]

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