Dataset Information

Structural brain abnormalities in children and young adults with severe chronic kidney disease.

ABSTRACT:

Background

The pathophysiology of neurological dysfunction in severe chronic kidney disease (CKD) in children and young adults is largely unknown. We aimed to investigate brain volumes and white matter integrity in this population and explore brain structure under different treatment modalities.

Methods

This cross-sectional study includes 24 patients with severe CKD (eGFR < 30) aged 8-30 years (median = 18.5, range = 9.1-30.5) on different therapy modalities (pre-dialysis, n = 7; dialysis, n = 7; transplanted, n = 10) and 21 healthy controls matched for age, sex, and parental educational level. Neuroimaging targeted brain volume using volumetric analysis on T1 scans and white matter integrity with tract-based spatial statistics and voxel-wise regression on diffusion tensor imaging (DTI) data.

Results

CKD patients had lower white matter integrity in a widespread cluster of primarily distal white matter tracts compared to healthy controls. Furthermore, CKD patients had smaller volume of the nucleus accumbens relative to healthy controls, while no evidence was found for abnormal volumes of gray and white matter or other subcortical structures. Longer time since successful transplantation was related to lower white matter integrity. Exploratory analyses comparing treatment subgroups suggest lower white matter integrity and smaller volume of the nucleus accumbens in dialysis and transplanted patients relative to healthy controls.

Conclusions

Young CKD patients seem at risk for widespread disruption of white matter integrity and to some extent smaller subcortical volume (i.e., nucleus accumbens). Especially patients on dialysis therapy and patients who received a kidney transplant may be at risk for disruption of white matter integrity and smaller volume of the nucleus accumbens.

SUBMITTER: Lijdsman S

PROVIDER: S-EPMC9023396 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Publications

Structural brain abnormalities in children and young adults with severe chronic kidney disease.

Lijdsman Sophie S Königs Marsh M van Sandwijk Marit S MS Bouts Antonia H AH van Hoeck Koen K de Jong Huib H Engelen Marc M Oosterlaan Jaap J Bemelman Frederike J FJ Oostrom Kim J KJ Groothoff Jaap W JW

Pediatric nephrology (Berlin, Germany) 20211120 5

<h4>Background</h4>The pathophysiology of neurological dysfunction in severe chronic kidney disease (CKD) in children and young adults is largely unknown. We aimed to investigate brain volumes and white matter integrity in this population and explore brain structure under different treatment modalities.<h4>Methods</h4>This cross-sectional study includes 24 patients with severe CKD (eGFR < 30) aged 8-30 years (median = 18.5, range = 9.1-30.5) on different therapy modalities (pre-dialysis, n = 7; ...[more]

PMID: 34800137

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Dataset Information

Structural brain abnormalities in children and young adults with severe chronic kidney disease.

Background

Methods

Results

Conclusions

Publications

Structural brain abnormalities in children and young adults with severe chronic kidney disease.

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