Dataset Information

The Anti-Inflammatory Properties of Licorice (Glycyrrhiza glabra)-Derived Compounds in Intestinal Disorders.

ABSTRACT: Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer (CRC), are a significant source of morbidity and mortality worldwide. Epidemiological data have shown that IBD patients are at an increased risk for the development of CRC. IBD-associated cancer develops against a background of chronic inflammation and oxidative stress, and their products contribute to cancer development and progression. Therefore, the discovery of novel drugs for the treatment of intestinal diseases is urgently needed. Licorice (Glycyrrhiza glabra) has been largely used for thousands of years in traditional Chinese medicine. Licorice and its derived compounds possess antiallergic, antibacterial, antiviral, anti-inflammatory, and antitumor effects. These pharmacological properties aid in the treatment of inflammatory diseases. In this review, we discuss the pharmacological potential of bioactive compounds derived from Licorice and addresses their anti-inflammatory and antioxidant properties. We also discuss how the mechanisms of action in these compounds can influence their effectiveness and lead to therapeutic effects on intestinal disorders.

SUBMITTER: Leite CDS

PROVIDER: S-EPMC9025446 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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The Anti-Inflammatory Properties of Licorice (<i>Glycyrrhiza glabra</i>)-Derived Compounds in Intestinal Disorders.

Leite Camila Dos Santos CDS Bonafé Gabriel Alves GA Carvalho Santos Juliana J Martinez Carlos Augusto Real CAR Ortega Manoela Marques MM Ribeiro Marcelo Lima ML

International journal of molecular sciences 20220408 8

Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer (CRC), are a significant source of morbidity and mortality worldwide. Epidemiological data have shown that IBD patients are at an increased risk for the development of CRC. IBD-associated cancer develops against a background of chronic inflammation and oxidative stress, and their products contribute to cancer development and progression. Therefore, the discovery of novel drugs for the treatment of intestinal di ...[more]

PMID: 35456938

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Project description:While salinity is increasingly becoming a prominent concern in arable farms around the globe, various treatments can be used for the mitigation of salt stress. Here, the effective presence of Azotobacter sp. inoculation (A1) and absence of inoculation (A0) was evaluated on Iranian licorice plants under NaCl stress (0 and 200 mM) (S0 and S1, respectively). In this regard, 16 Iranian licorice (Glycyrrhiza glabra L.) accessions were evaluated for the effects on photosynthesis and chlorophyll fluorescence. Leaf samples were measured for photosynthetic pigments (via a spectrophotometer), stomatal and trichome-related features (via SEM), along with several other morphological and biochemical features. The results revealed an increase in the amount of carotenoids that was caused by bacterial inoculation, which was 28.3% higher than the non-inoculated treatment. Maximum initial fluorescence intensity (F0) (86.7) was observed in the ‘Bardsir’ accession. Meanwhile, the highest variable fluorescence (Fv), maximal fluorescence intensity (Fm), and maximum quantum yield (Fv/Fm) (0.3, 0.4, and 0.8, respectively) were observed in the ‘Eghlid’ accession. Regarding anatomical observations of the leaf structure, salinity reduced stomatal density but increased trichome density. Under the effect of bacterial inoculation, salinity stress was mitigated. With the effect of bacterial inoculation under salinity stress, stomatal length and width increased, compared to the condition of no bacterial inoculation. Minimum malondialdehyde content was observed in ‘Mahabad’ accession (17.8 μmol/g FW). Principle component analysis (PCA) showed that ‘Kashmar’, ‘Sepidan’, ‘Bajgah’, ‘Kermanshah’, and ‘Taft’ accessions were categorized in the same group while being characterized by better performance in the aerial parts of plants. Taken together, the present results generally indicated that selecting the best genotypes, along with exogenous applications of Azotobacter, can improve the outcomes of licorice cultivation for industrial purposes under harsh environments.

Project description:BackgroundGlycyrrhiza glabra L. is a medicinal and industrial plant that has gone extinct due to different abiotic stress caused by climate change. To understand how the plant-associated microorganism can support this plant under salinity, we collected sixteen Iranian accessions of G. glabra L., inoculated their rhizomes with Azotobacter sp. (two levels, bacterial treatments, and no-bacterial treatments, and grown them under salinity stress (NaCl levels; 0, and 200 mM).ResultsTwo accessions of Bardsir and Bajgah significantly showed higher resistant to salinity, for example by increasing crown diameter (11.05 and 11 cm, respectively) compared to an average diameter of 9.5 in other accessions. Azotobacter inoculation caused a significant increase in plant height and crown diameter. Among studied accessions, Kashmar (46.21%) and Ilam (44.95%) had the highest rate of membrane stability index (MSI). Evaluation of enzyme activity represented that bacterial application under salinity, increased polyphenol oxidase (PPO) (0.21 U mg-1 protein), peroxidase (POD) (3.09 U mg-1 protein U mg-1 protein), and phenylalanine ammonia-lyase (PAL) (17.85 U mg-1 protein) activity. Darab accession showed the highest increase (6.45%) in antioxidant potential compared with all studied accessions under Azotobacter inoculation. According to principal component analysis (PCA), it was found that the accession of Meshkinshahr showed a more remarkable ability to activate its enzymatic defense system under salt stress. Also, three accessions of Meshkinshahr, Eghlid, and Ilam were categorized in separated clusters than other accessions regarding various studied treatments.ConclusionAnalysis indicated that five accessions of Meshkinshahr, Rabt, Piranshahr, Bardsir, and Kermanshah from the perspective of induced systematic resistance are the accessions that showed a greater morphophysiological and biochemical outcome under salinity. This study suggested that, inoculation of with Azotobacter on selected accession can relieve salt stress and support industrial mass production under abiotic condition.

Project description:Cancers represent a significant cause of morbidity and mortality worldwide. They also impose a large economic burden on patients, their families, and health insurance systems. Notably, cancers and the adverse reactions to their therapeutic options, chemotherapy and radiotherapy, dramatically affect the quality of life of afflicted patients. Therefore, developing approaches to manage chemotherapy- and radiotherapy-induced adverse reactions gained greater attention in recent years. Glycyrrhiza glabra (licorice), a perennial plant that is one of the most frequently used herbs in traditional Chinese medicine, has been heavily investigated in relation to cancer therapy. Licorice/licorice-related regimes, used in combination with chemotherapy, may improve the adverse effects of chemotherapy. However, there is little awareness of licorice-containing herbs alleviating reactions to radiotherapy and chemotherapy, or to other induced adverse reactions in cancer treatment. We aimed to provide a descriptive review, and to emphasize the possibility that licorice-related medicines could be used as an adjuvant regimen with chemotherapy to improve quality of life (QoL) and to reduce side effects, thus, improving compliance with chemotherapy. The experimental method involved searching different databases, including PubMed, the Cochrane Library, and Wang Fang database, as of May 2022, to identify any relevant studies. Despite a lack of high-quality and large-scale randomized controlled trials, we still discovered the potential benefits of licorice-containing herbs from published clinical studies. These studies find that licorice-containing herbs, and their active ingredients, reduce the adverse reactions caused by chemotherapy and radiotherapy, and improve the QoL of patients. This comprehensive review will serve as a cornerstone to encourage more scientists to evaluate and develop effective Traditional Chinese medicine prescriptions to improve the side effects of chemotherapy and radiation therapy.

Dataset Information

The Anti-Inflammatory Properties of Licorice (Glycyrrhiza glabra)-Derived Compounds in Intestinal Disorders.

Publications

The Anti-Inflammatory Properties of Licorice (<i>Glycyrrhiza glabra</i>)-Derived Compounds in Intestinal Disorders.

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