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Colonization of Group B Streptococcus in Pregnant Women and Their Neonates from a Sri Lankan Hospital.


ABSTRACT: We investigated the molecular epidemiology of Streptococcus agalactiae (Group B Streptococcus, GBS) from carriage in a cohort of pregnant mothers and their respective newborns in a Teaching Hospital in Sri Lanka. GBS vaginal carriage was assessed on pregnant mothers at pre-delivery (n = 250), post-delivery (n = 130), and from peri-rectal swabs of neonates (n = 159) in a prospective study. All colonizing, non-duplicate GBS isolates (n = 60) were analyzed for antimicrobial susceptibilities, capsular serotyping, and whole-genome sequencing (WGS). The percentage of GBS carriage in mothers in the pre-delivery and post-delivery cohorts were 11.2% (n = 28) and 19.2% (n = 25), respectively, and 4.4% (n = 7) in neonates. GBS isolates predominantly belonged to serotype VI (17/60, 28.3%). The isolates spanned across 12 sequence types (STs), with ST1 (24/60, 40%) being the most predominant ST. Concomitant resistance to erythromycin, tetracyclines, and gentamicin was observed in eight strains (13.3%). WGS revealed the presence of antimicrobial resistance genes including ermA (5/60), mefA (1/60), msrD (1/60), and tetLMO (2/60, 28/60, and 1/60, respectively) among 60 strains. The study provides insight into the diversity of vaccine targets of GBS since serotype VI is yet to be covered in the vaccine development program.

SUBMITTER: Sapugahawatte DN 

PROVIDER: S-EPMC9029214 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Colonization of Group B <i>Streptococcus</i> in Pregnant Women and Their Neonates from a Sri Lankan Hospital.

Sapugahawatte Dulmini Nanayakkara DN   Li Carmen C   Liyanapathirana Veranja V   Kandauda Chaminda C   Gihan Champika C   Zhu Chendi C   Lo Norman Wai Sing NWS   Wong Kam Tak KT   Ip Margaret M  

Pathogens (Basel, Switzerland) 20220323 4


We investigated the molecular epidemiology of <i>Streptococcus agalactiae</i> (Group B <i>Streptococcus</i>, GBS) from carriage in a cohort of pregnant mothers and their respective newborns in a Teaching Hospital in Sri Lanka. GBS vaginal carriage was assessed on pregnant mothers at pre-delivery (<i>n</i> = 250), post-delivery (<i>n</i> = 130), and from peri-rectal swabs of neonates (<i>n</i> = 159) in a prospective study. All colonizing, non-duplicate GBS isolates (<i>n</i> = 60) were analyzed  ...[more]

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