Oncology Drug Repurposing for Sepsis Treatment.
Ontology highlight
ABSTRACT:
SUBMITTER: Rumienczyk I
PROVIDER: S-EPMC9030585 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Publications
Oncology Drug Repurposing for Sepsis Treatment.
Rumienczyk Izabela I Kulecka Maria M Statkiewicz Małgorzata M Ostrowski Jerzy J Mikula Michal M
Biomedicines 20220417 4
Sepsis involves life-threatening organ dysfunction caused by a dysregulated host response to infection. Despite three decades of efforts and multiple clinical trials, no treatment, except antibiotics and supportive care, has been approved for this devastating syndrome. Simultaneously, numerous preclinical studies have shown the effectiveness of oncology-indicated drugs in ameliorating sepsis. Here we focus on cataloging these efforts with both oncology-approved and under-development drugs that h ...[more]
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