Network-wise concordance of multimodal neuroimaging features across the Alzheimer's disease continuum.

ABSTRACT:

Background

Concordance between cortical atrophy and cortical glucose hypometabolism within distributed brain networks was evaluated among cerebrospinal fluid (CSF) biomarker-defined amyloid/tau/neurodegeneration (A/T/N) groups.

Method

We computed correlations between cortical thickness and fluorodeoxyglucose metabolism within 12 functional brain networks. Differences among A/T/N groups (biomarker normal [BN], Alzheimer's disease [AD] continuum, suspected non-AD pathologic change [SNAP]) in network concordance and relationships to longitudinal change in cognition were assessed.

Results

Network-wise markers of concordance distinguish SNAP subjects from BN subjects within the posterior multimodal and language networks. AD-continuum subjects showed increased concordance i

SUBMITTER: Stocks J 

PROVIDER: S-EPMC9043119 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature