Dataset Information

Spectral-domain OCT measurements in obesity: A systematic review and meta-analysis.

ABSTRACT:

Background

Previous studies proposed possible applications of spectral-domain optical coherence tomography (SD-OCT) measurements in prognosticating pathologies observed in overweight/obesity, including ocular, vascular, and neurologic consequences. Therefore, we conducted a systematic review and meta-analysis to investigate the changes in the in SD-OCT measurements of the patients with higher body mass index (BMI) compared to normal weight individuals.

Materials and methods

We conducted a systematic search on PubMed, Scopus, and Embase. The search results underwent two-phase title/abstract and full-text screenings. We then analyzed SD-OCT measurements differences in patients with high BMI and controls, and performed meta-regression, sub-group analysis, quality assessment, and publication bias assessment. The measurements included macular thickness, cup to disc ratio, ganglion cell-inner plexiform layer (GC-IPL) and its sub-sectors, RNFL and peripapillary RNFL (pRNFL) and their sub-layers, and choroidal thickness and its sub-sectors.

Results

19 studies were included in this meta-analysis accounting for 1813 individuals, 989 cases and 824 controls. There was an overall trend towards decreased thickness in high BMI patients, but only two measurements reached statistical significance: temporal retinal nerve fiber layer (RNFL) (Standardized mean difference (SMD): -0.33, 95% confidence interval (CI): -0.53 to -0.14, p<0.01) and the choroidal region 1.0 mm nasal to fovea (SMD: -0.38, 95% CI: -0.60 to -0.16, p<0.01).

Conclusion

Some ocular layers are thinner in patients with higher BMI than the controls. These SD-OCT measurements might correlate with adverse events related to increased body weight and have prognostic abilities. As SD-OCT is a robust, rapid and non-invasive tool, future guidelines and studies are needed to evaluate the possibility of their integration into care of the patients with obesity.

SUBMITTER: Salehi MA

PROVIDER: S-EPMC9045631 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Spectral-domain OCT measurements in obesity: A systematic review and meta-analysis.

Salehi Mohammad Amin MA Karimi Amirali A Mohammadi Soheil S Arevalo J Fernando JF

PloS one 20220427 4

<h4>Background</h4>Previous studies proposed possible applications of spectral-domain optical coherence tomography (SD-OCT) measurements in prognosticating pathologies observed in overweight/obesity, including ocular, vascular, and neurologic consequences. Therefore, we conducted a systematic review and meta-analysis to investigate the changes in the in SD-OCT measurements of the patients with higher body mass index (BMI) compared to normal weight individuals.<h4>Materials and methods</h4>We con ...[more]

PMID: 35476846

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Dataset Information

Spectral-domain OCT measurements in obesity: A systematic review and meta-analysis.

Background

Materials and methods

Results

Conclusion

Publications

Spectral-domain OCT measurements in obesity: A systematic review and meta-analysis.

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