Dataset Information

Reduced spread of influenza and other respiratory viral infections during the COVID-19 pandemic in southern Puerto Rico.

ABSTRACT:

Introduction

Impacts of COVID-19 mitigation measures on seasonal respiratory viruses is unknown in sub-tropical climates.

Methods

We compared weekly testing and test-positivity of respiratory infections in the 2019-2020 respiratory season to the 2012-2018 seasons in southern Puerto Rico using Wilcoxon signed rank tests.

Results

Compared to the average for the 2012-2018 seasons, test-positivity was significantly lower for Influenza A (p<0.001) & B (p<0.001), respiratory syncytial virus (RSV) (p<0.01), respiratory adenovirus (AdV) (p<0.05), and other respiratory viruses (p<0.001) following March 2020 COVID-19 stay at home orders.

Conclusions

Mitigation measures and behavioral social distancing choices may have reduced respiratory viral spread in southern Puerto Rico.

SUBMITTER: Quandelacy TM

PROVIDER: S-EPMC9045654 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Reduced spread of influenza and other respiratory viral infections during the COVID-19 pandemic in southern Puerto Rico.

Quandelacy Talia M TM Adams Laura E LE Munoz Jorge J Santiago Gilberto A GA Kada Sarah S Johansson Michael A MA Alvarado Luisa I LI Rivera-Amill Vanessa V Paz-Bailey Gabriela G

PloS one 20220427 4

<h4>Introduction</h4>Impacts of COVID-19 mitigation measures on seasonal respiratory viruses is unknown in sub-tropical climates.<h4>Methods</h4>We compared weekly testing and test-positivity of respiratory infections in the 2019-2020 respiratory season to the 2012-2018 seasons in southern Puerto Rico using Wilcoxon signed rank tests.<h4>Results</h4>Compared to the average for the 2012-2018 seasons, test-positivity was significantly lower for Influenza A (p<0.001) & B (p<0.001), respiratory sync ...[more]

PMID: 35476785

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Project description:The purpose of the study was to assess the patterns of global gene expression in peripheral blood cells and uncover the complex dynamics of host response to ARIs such as pandemic H1N1. To understand the molecular bases and network orchestration of host responses, we prospectively enrolled 1610 healthy adults in the fall of 2009 and 2010, followed the subjects with influenza-like illness (N=133) for 3 weeks, and examined changes in their peripheral blood gene expression. We discovered distinct phases of the host response spanning 6 days after infection, and identified genes that differentiate influenza from non-influenza virus infection. We examined pre- and post-infection anti-influenza antibody titers defining novel gene expression correlates. Healthy adults were invited to enroll to be followed for acute respiratory illness (ARI) through two consecutive influenza seasons 2009-2010 and 2010-2011. After subjects provided consent, baseline blood specimens were obtained during enrollment. Subjects were given thermometers and instructions to call and report for evaluation within 48 hours of ARI onset. Those persons who had a new ARI were seen within 48 hours of onset (day 0) and 2, 4, and 6 days later for repeat evaluation, blood specimen collections, and medical care (including the antiviral zanamivir if indicated) and 21 days later for collection of convalescent specimens. Nasal wash samples were collected for virus detection by RT-PCR on day 0 and day 2. Surveillance for influenza was terminated after 5.5 months; all subjects were asked to return for specimen collection and to provide a medical and ARI history in spring of next year. Serum specimens obtained at baseline, day 0 and day 21 visits for illnesses, and the terminal visit were tested simultaneously using hemagglutination-inhibition (HAI) antibody assay for Influenza H1N1, H3N2, and Influenza B strains. Peripheral blood RNA (PaxGene) obtained from blood specimens at each visit were analyzed using Illumina Human HT-12 v4. The study was repeated 2010-2011. A total of 880 arrays, corresponding to 133 individuals, passed quality control and are included in this data set.

Dataset Information

Reduced spread of influenza and other respiratory viral infections during the COVID-19 pandemic in southern Puerto Rico.

Introduction

Methods

Results

Conclusions

Publications

Reduced spread of influenza and other respiratory viral infections during the COVID-19 pandemic in southern Puerto Rico.

Similar Datasets

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