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Preparation of cyclic imides from alkene-tethered amides: application of homogeneous Cu(ii) catalytic systems.

ABSTRACT: A Cu-based homogeneous catalytic system was proposed for the preparation of imides from alkene-tethered amides. Here, O₂ acted as a terminal oxidant and a cheap and easily available oxygen source. The cleavage of C[double bond, length as m-dash]C bonds and the formation of C-N bonds were catalyzed by Cu(ii) salts with proper nitrogen-containing ligands under 100 °C. The synthesis approach has potential applications in pharmaceutical syntheses. Moreover, scaled-up experiments confirmed the practical applicability.

SUBMITTER: Liu Z

PROVIDER: S-EPMC9049870 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Preparation of cyclic imides from alkene-tethered amides: application of homogeneous Cu(ii) catalytic systems.

Liu Zhenghui Z Wang Peng P Ou Hualin H Yan Zhenzhong Z Chen Suqing S Tan Xingxing X Yu Dongkun D Zhao Xinhui X Mu Tiancheng T

RSC advances 20200221 13

A Cu-based homogeneous catalytic system was proposed for the preparation of imides from alkene-tethered amides. Here, O2 acted as a terminal oxidant and a cheap and easily available oxygen source. The cleavage of C[double bond, length as m-dash]C bonds and the formation of C-N bonds were catalyzed by Cu(ii) salts with proper nitrogen-containing ligands under 100 °C. The synthesis approach has potential applications in pharmaceutical syntheses. Moreover, scaled-up experiments confirmed ...[more]

PMID: 35492186

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