Synthetic progress toward the marine natural product zamamiphidin A.
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ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC9050630 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Synthetic progress toward the marine natural product zamamiphidin A.
Wang Hao H Tian Di D Meng Zhaoxiang Z Chen Zhihao Z Xue Fei F Liu Xiao-Yu XY Song Hao H Qin Yong Y
RSC advances 20200324 20
An asymmetric synthetic approach to the octahydrofuro[3,4-<i>b</i>]pyridine framework of marine natural product zamamiphidin A has been described. The key steps include an asymmetric Michael addition of (<i>R</i>)-<i>N-tert</i>-butanesulfinyl imidate with enamidomalonate to install the C10 stereocenter, an intramolecular alkoxide exchange/Michael addition/hydrogenation sequence to construct the bicyclic ring system. ...[more]
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