Ontology highlight
ABSTRACT:
SUBMITTER: Sechi LA
PROVIDER: S-EPMC90526 | biostudies-literature | 2001 Jun
REPOSITORIES: biostudies-literature
Sechi L A LA Zanetti S S Sanguinetti M M Molicotti P P Romano L L Leori G G Delogu G G Boccia S S La Sorda M M Fadda G G
Antimicrobial agents and chemotherapy 20010601 6
Fourteen of 22 (68%) Mycobacterium bovis strains isolated from cattle in Sardinia were found to be resistant to rifampin and isoniazid. Analysis of the rpoB and the katG, oxyR-ahpC, and inhA gene regions of these strains was performed in order to investigate the molecular basis of rifampin and isoniazid resistance, respectively. The most frequent mutation, encountered in 6 of 10 strains (60%), was in the rpoB gene; it occurred, at codon position 521 and resulted in leucine changed to proline. Th ...[more]