Dataset Information

Lipase elevation on admission predicts worse clinical outcomes in patients with COVID-19.

ABSTRACT:

Background and objectives

Hyperlipasemia is highly prevalent among coronavirus disease 2019 (COVID-19) patients. The aim of this study was to assess the effect of lipase activity, measured at the time of admission, on the clinical course and mortality in COVID-19 patients.

Methods

The population of this study comprised 12,139 patients who were hospitalized due to COVID-19 between June 2020 and June 2021 in a pandemic hospital. Of these, 8819 patients were excluded from the study due to missing data, four patients were excluded due to a diagnosis of acute pancreatitis (according to the revised Atlanta criteria), and 72 patients were excluded due to alcohol use or having a history of chronic pancreatitis. The final study sample consisted of the remaining 3244 COVID-19 patients. Laboratory results, intensive care unit (ICU) follow-up periods, the need for mechanical ventilation, and mortality rates were compared between the normal lipase activity and high lipase activity groups.

Results

There were 968 (29.8%) patients with high lipase activity at the time of admission. The rate of ICU admission was 36.1% vs. 9.9% (p < 0.001), mechanical ventilation requirement rates were 33.7% vs. 8.3% (p < 0.001), and mortality rates were as 24.6% vs. 6.4% (p < 0.001) in the high lipase activity group compared to the normal lipase activity group. Multivariate regression analysis revealed that high lipase activity was an independent factor in predicting mortality in hospitalized COVID-19 patients (odds ratio [OR]: 3.191, p < 0.001).

Conclusion

Elevated lipase activity without acute pancreatitis at the time of admission in COVID-19 patients was determined as an independent predictor of poor prognosis.

SUBMITTER: Kiyak M

PROVIDER: S-EPMC9054729 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

Lipase elevation on admission predicts worse clinical outcomes in patients with COVID-19.

Kiyak Mevlut M Düzenli Tolga T

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20220430 5

<h4>Background and objectives</h4>Hyperlipasemia is highly prevalent among coronavirus disease 2019 (COVID-19) patients. The aim of this study was to assess the effect of lipase activity, measured at the time of admission, on the clinical course and mortality in COVID-19 patients.<h4>Methods</h4>The population of this study comprised 12,139 patients who were hospitalized due to COVID-19 between June 2020 and June 2021 in a pandemic hospital. Of these, 8819 patients were excluded from the study d ...[more]

PMID: 35537935

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Dataset Information

Lipase elevation on admission predicts worse clinical outcomes in patients with COVID-19.

Background and objectives

Methods

Results

Conclusion

Publications

Lipase elevation on admission predicts worse clinical outcomes in patients with COVID-19.

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