Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Q
PROVIDER: S-EPMC9055073 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Zhao Qi Q Wang Feng F Chen Yan-Xing YX Chen Shifu S Yao Yi-Chen YC Zeng Zhao-Lei ZL Jiang Teng-Jia TJ Wang Ying-Nan YN Wu Chen-Yi CY Jing Ying Y Huang You-Sheng YS Zhang Jing J Wang Zi-Xian ZX He Ming-Ming MM Pu Heng-Ying HY Mai Zong-Jiong ZJ Wu Qi-Nian QN Long Renwen R Zhang Xiaoni X Huang Tanxiao T Xu Mingyan M Qiu Miao-Zheng MZ Luo Hui-Yan HY Li Yu-Hong YH Zhang Dong-Shen DS Jia Wei-Hua WH Chen Gong G Ding Pei-Rong PR Li Li-Ren LR Lu Zheng-Hai ZH Pan Zhi-Zhong ZZ Xu Rui-Hua RH
Nature communications 20220429 1
The genetic basis of colorectal cancer (CRC) and its clinical associations remain poorly understood due to limited samples or targeted genes in current studies. Here, we perform ultradeep whole-exome sequencing on 1015 patients with CRC as part of the ChangKang Project. We identify 46 high-confident significantly mutated genes, 8 of which mutate in 14.9% of patients: LYST, DAPK1, CR2, KIF16B, NPIPB15, SYTL2, ZNF91, and KIAA0586. With an unsupervised clustering algorithm, we propose a subtyping s ...[more]