Fabrication of hierarchically porous superhydrophilic polycaprolactone monolith based on nonsolvent-thermally induced phase separation.

ABSTRACT: Monoliths with a continuous porous structure are of great interest due to high transfer efficiency and large surface area in environmental and tissue engineering fields. This study demonstrated a facile method to prepare PCL monoliths with hierarchically porous structure by nonsolvent-thermally induced phase separation. A suitable mixed solvent mixture using ethanol as nonsolvent reduced the amount of dioxane and provided PCL monoliths with three levels of structures. The monolith structure was easily controlled by changing the fabrication parameters, such as the nonsolvent, the temperature of phase separation, the concentration of the PCL. Finally, the superhydrophilic monolith was easily obtained by polydopamine surface modification. The easy way of fabrication of a hierarchically porous PCL monolith with superhydrophilicity will find applications such as in tissue engineering and purification.

SUBMITTER: Cao Y 

PROVIDER: S-EPMC9055430 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature