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Smart magnetic nanopowder based on the manganite perovskite for local hyperthermia.

ABSTRACT: For many medical applications related to diagnosis and treatment of cancer disease, hyperthermia plays an increasingly important role as a local heating method, where precise control of temperature and parameters of the working material is strongly required. Obtaining a smart material with "self-controlled" heating in a desirable temperature range is a relevant task. For this purpose, the nanopowder of manganite perovskite with super-stoichiometric manganese has been synthesized, which consists of soft spherical-like ferromagnetic nanoparticles with an average size of 65 nm and with a narrow temperature range of the magnetic phase transition at 42 °C. Based on the analysis of experimental magnetic data, a specific loss power has been calculated for both quasi-stable and relaxation hysteresis regions. It has been shown that the local heating of the cell structures to 42 °C may occur for a short time (∼1.5 min.) Upon reaching 42 °C, the heating is stopped due to transition of the nanopowder to the paramagnetic state. The obtained results demonstrate the possibility of using synthesized nanopowder as a smart magnetic nanomaterial for local hyperthermia with automatic heating stabilization in the safe range of hyperthermia without the risk of mechanical damage to cell structures.

SUBMITTER: Pashchenko AV

PROVIDER: S-EPMC9056338 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Smart magnetic nanopowder based on the manganite perovskite for local hyperthermia.

Pashchenko A V AV Liedienov N A NA Fesych I V IV Li Quanjun Q Pitsyuga V G VG Turchenko V A VA Pogrebnyak V G VG Liu Bingbing B Levchenko G G GG

RSC advances 20200820 51

For many medical applications related to diagnosis and treatment of cancer disease, hyperthermia plays an increasingly important role as a local heating method, where precise control of temperature and parameters of the working material is strongly required. Obtaining a smart material with "self-controlled" heating in a desirable temperature range is a relevant task. For this purpose, the nanopowder of manganite perovskite with super-stoichiometric manganese has been synthesized, which consists ...[more]

PMID: 35516065

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Project description:In this study, Mg1-xCoxFe2O4 (0≤x ≤ 1 with ∆x = 0.1) or MCFO nanoparticles were synthesized using a chemical co-precipitation method and annealed at 200, 400, 600, and 800°C respectively to investigate the structural properties of the materials by X-ray diffractometer (XRD), transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FTIR). Controlled annealing increased particle size for each value of x. The aim was to investigate how specific loss power (SLP) and maximum temperature (Tmax) during local magnetic hyperthermia were affected by structural alterations associated with particle size and composition. The lattice parameter, X-ray density, ionic radius, hopping length, bond length, cation-cation distance, and cation-anion distance increase with an increase in Co2+ content. Raman and FTIR spectroscopy reveal changes in cation distribution with Co2+ content and particle size. Magnetic properties measured by the physical property measurement system (PPMS) showed saturation magnetization (Ms), coercivity (Hc), remanent magnetization (Mr/Ms), and anisotropy constant (K1) of the Mg1-xCoxFe2O4 nanoparticles increase with Co2+ content and particle size. When exposed to an rf magnetic field, the nanohybrids experienced an increase in both the SLP (specific loss power) and Tmax (maximum temperature) as the particle size initially increased. However, these values reached their peak at critical particle size and subsequently decreased. This occurs since a modest increase in anisotropy, resulting from the presence of Co2+ and larger particle size, facilitates Néel and Brownian relaxation. However, for high anisotropy values and particle size, the Néel and Brownian relaxations are hindered, leading to the emergence of a critical size. The critical size increases as the Co2+ content decreases, but it decreases as the Co2+ content increases, a consequence of higher anisotropy with the increase in Co2+. Additionally, it is noteworthy that the maximum temperature (Tmax) rises as the concentration of nanohybrids grows, but the specific loss power (SLP) decreases. An increased concentration of chitosan-MCFO nanohybrids inhibits both the Néel and Brownian relaxation processes, reducing specific loss power.

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Smart magnetic nanopowder based on the manganite perovskite for local hyperthermia.

Publications

Smart magnetic nanopowder based on the manganite perovskite for local hyperthermia.

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