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Mother-to-child transmission of human immunodeficiency virus, hepatitis B virus and hepatitis C virus among pregnant women with single, dual or triplex infections of human immunodeficiency virus, hepatitis B virus and hepatitis C virus in Nigeria: A systematic review and meta-analysis.


ABSTRACT: Objectives: To systematically review literature and identify mother-to-child transmission rates of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus among pregnant women with single, dual, or triplex infections of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in Nigeria. PRISMA guidelines were employed. Searches were on 19 February 2021 in PubMed, Google Scholar and CINAHL on studies published from 1 February 2001 to 31 January 2021 using keywords: "MTCT," "dual infection," "triplex infection," "HIV," "HBV," and "HCV." Studies that reported mother-to-child transmission rate of at least any of human immunodeficiency virus, hepatitis B virus and hepatitis C virus among pregnant women and their infant pairs with single, dual, or triplex infections of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in Nigeria irrespective of publication status or language were eligible. Data were extracted independently by two authors with disagreements resolved by a third author. Meta-analysis was performed using the random effects model of DerSimonian and Laird, to produce summary mother-to-child transmission rates in terms of percentage with 95% confidence interval. Protocol was prospectively registered in PROSPERO: CRD42020202070. The search identified 849 reports. After screening titles and abstracts, 25 full-text articles were assessed for eligibility and 18 were included for meta-analysis. We identified one ongoing study. Pooled mother-to-child transmission rates were 2.74% (95% confidence interval: 2.48%-2.99%; 5863 participants; 15 studies) and 55.49% (95% confidence interval: 35.93%-75.04%; 433 participants; three studies), among mother-infant pairs with mono-infection of human immunodeficiency virus and hepatitis B virus, respectively, according to meta-analysis. Overall, the studies showed a moderate risk of bias. The pooled rate of mother-to-child transmission of human immunodeficiency virus was 2.74% and hepatitis B virus was 55.49% among mother-infant pairs with mono-infection of HIV and hepatitis B virus, respectively. No data exists on rates of mother-to-child transmission of hepatitis C virus on mono-infection or mother-to-child transmission of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus among mother-infant pairs with dual or triplex infection of HIV, hepatitis B virus and HCV in Nigeria.

SUBMITTER: Eleje GU 

PROVIDER: S-EPMC9058348 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Mother-to-child transmission of human immunodeficiency virus, hepatitis B virus and hepatitis C virus among pregnant women with single, dual or triplex infections of human immunodeficiency virus, hepatitis B virus and hepatitis C virus in Nigeria: A systematic review and meta-analysis.

Eleje George Uchenna GU   Onubogu Chinyere Ukamaka CU   Fiebai Preye Owen PO   Mbachu Ikechukwu Innocent II   Akaba Godwin Otuodichinma GO   Loto Olabisi Morebise OM   Usman Hadiza Abdullahi HA   Rabiu Ayyuba A   Chibuzor Moriam Taiwo MT   Chukwuanukwu Rebecca Chinyelu RC   Joe-Ikechebelu Ngozi Nneka NN   Nwankwo Chike Henry CH   Kalu Stephen Okoroafor SO   Ogbuagu Chukwuanugo Nkemakonam CN   Chukwurah Shirley Nneka SN   Uzochukwu Chinwe Elizabeth CE   Oppah Ijeoma Chioma IC   Ahmed Aishat A   Egeonu Richard Obinwanne RO   Jibuaku Chiamaka Henrietta CH   Inuyomi Samuel Oluwagbenga SO   Adesoji Bukola Abimbola BA   Anyang Ubong Inyang UI   Ogwaluonye Uchenna Chukwunonso UC   Emeka Ekene Agatha EA   Igue Odion Emmanuel OE   Okoro Ogbonna Dennis OD   Aja Prince Ogbonnia PO   Chidozie Chiamaka Perpetua CP   Ibrahim Hadiza Sani HS   Aliyu Fatima Ele FE   Numan Aisha Ismaila AI   Omoruyi Solace Amechi SA   Umeononihu Osita Samuel OS   Okoro Chukwuemeka Chukwubuikem CC   Nwaeju Ifeanyi Kingsley IK   Onwuegbuna Arinze Anthony AA   Umeh Eric Okechukwu EO   Nweje Sussan Ifeyinwa SI   Eleje Lydia Ijeoma LI   Ajuba Ifeoma Clara IC   Ikwuka David Chibuike DC   Igbodike Emeka Philip EP   Chigbo Chisom God'swill CG   Ebubedike Uzoamaka Rufina UR   Okafor Chigozie Geoffrey CG   Obiegbu Nnaedozie Paul NP   Yakasai Ibrahim Adamu IA   Ezechi Oliver Chukwujekwu OC   Ikechebelu Joseph Ifeanyichukwu JI  

SAGE open medicine 20220428


<b>Objectives:</b> To systematically review literature and identify mother-to-child transmission rates of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus among pregnant women with single, dual, or triplex infections of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in Nigeria. PRISMA guidelines were employed. Searches were on 19 February 2021 in PubMed, Google Scholar and CINAHL on studies published from 1 February 2001 to 31 January 2021 using keyw  ...[more]

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