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Enantioselective one-pot synthesis of 4H-chromene derivatives catalyzed by a chiral Ni(ii) complex.

ABSTRACT: A Ni(ii)-bis(oxazoline) complex and p-TSOH are used to form enantioenriched 4H-chromenes from ortho-quinone methides (o-QMs) and dicarbonyls, providing the desired products in up to 95% ee. The method is compatible with various β-ketoester substrates, and the products obtained could be converted into biologically active 4H-chromene derivatives.

SUBMITTER: Yu X

PROVIDER: S-EPMC9058437 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Enantioselective one-pot synthesis of 4H-chromene derivatives catalyzed by a chiral Ni(ii) complex.

Yu Xuan X Lan Wenjie W Li Jiaqi J Bai Hui H Qin Zhaohai Z Fu Bin B

RSC advances 20201216 72

A Ni(ii)-bis(oxazoline) complex and p-TSOH are used to form enantioenriched 4H-chromenes from ortho-quinone methides (o-QMs) and dicarbonyls, providing the desired products in up to 95% ee. The method is compatible with various β-ketoester substrates, and the products obtained could be converted into biologically active 4H-chromene derivatives. ...[more]

PMID: 35517147

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