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ABSTRACT:
SUBMITTER: Stasiulewicz M
PROVIDER: S-EPMC9059127 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Stasiulewicz Marcin M Panuszko Aneta A Bruździak Piotr P Stangret Janusz J
The journal of physical chemistry. B 20220420 16
In this work, we investigated the influence of stabilizing (<i>N</i>,<i>N</i>,<i>N</i>-trimethylglycine) and destabilizing (urea) osmolytes on the hydration spheres of biomacromolecules in folded forms (<i>trpzip</i>-1 peptide and hen egg white lysozyme─<i>hewl</i>) and unfolded protein models (glycine─GLY and <i>N</i>-methylglycine─NMG) by means of infrared spectroscopy. GLY and NMG were clearly limited as minimal models for unfolded proteins and should be treated with caution. We isolated the ...[more]