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Solvent- and transition metal-free amide synthesis from phenyl esters and aryl amines.

ABSTRACT: A general, economical, and environmentally friendly method of amide synthesis from phenyl esters and aryl amines was developed. This new method has significant advantages compared to previously reported palladium-catalyzed approaches. The reaction is performed transition metal- and solvent-free, using a cheap and environmentally benign base, NaH. This approach enabled us to obtain target amides in high yields with high atom economy.

SUBMITTER: Rzhevskiy SA

PROVIDER: S-EPMC9059645 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Solvent- and transition metal-free amide synthesis from phenyl esters and aryl amines.

Rzhevskiy Sergey A SA Ageshina Alexandra A AA Chesnokov Gleb A GA Gribanov Pavel S PS Topchiy Maxim A MA Nechaev Mikhail S MS Asachenko Andrey F AF

RSC advances 20190111 3

A general, economical, and environmentally friendly method of amide synthesis from phenyl esters and aryl amines was developed. This new method has significant advantages compared to previously reported palladium-catalyzed approaches. The reaction is performed transition metal- and solvent-free, using a cheap and environmentally benign base, NaH. This approach enabled us to obtain target amides in high yields with high atom economy. ...[more]

PMID: 35518015

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