Dataset Information

Additive roles of tobacco and cannabis co-use in relation to delay discounting in a sample of heavy drinkers.

ABSTRACT:

Rationale

Alcohol use disorder (AUD) is associated with steeper delay discounting rates; however, it is unknown whether substance co-use, particularly cannabis use, has an additive effect on discounting rates among heavy drinkers. Furthermore, it is unclear whether substance co-use and delay discounting are independently associated with AUD severity.

Objectives

The purpose of this study was to determine whether alcohol, tobacco, and cannabis co-use impacts delay discounting rates. We also sought to determine whether substance co-use and delay discounting were associated with AUD symptom counts.

Methods

The study sample was culled from several human laboratory studies and consisted of 483 heavy drinking individuals who completed a baseline visit (prior to experimental procedures). Participants were divided into groups based on self-reported alcohol, tobacco, and cannabis use during the past 30 days: alcohol only (n = 184), alcohol + cigarettes (n = 89), alcohol + cannabis (n = 82), and tri-use (n = 128). We examined discounting rates across the 4 groups and used multiple linear regression to test whether co-use and delay discounting were associated with AUD symptoms.

Results

After adjusting for covariates, individuals in the alcohol + cannabis group and the tri-use group had steeper discounting rates relative to the alcohol-only group. In addition, tri-use and delay discounting rates were independently correlated with a greater number of AUD symptoms.

Conclusions

Delay discounting rates were significantly greater among subgroups reporting cannabis use providing partial support for an additive effect, while also highlighting the importance of co-use substance type. Both tri-use and delay discounting were associated with greater AUD severity, which may provide relevant intervention targets.

SUBMITTER: Nieto SJ

PROVIDER: S-EPMC9059652 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Additive roles of tobacco and cannabis co-use in relation to delay discounting in a sample of heavy drinkers.

Nieto Steven J SJ Venegas Alexandra A Burnette Elizabeth M EM MacKillop James J Ray Lara A LA

Psychopharmacology 20211015 5

<h4>Rationale</h4>Alcohol use disorder (AUD) is associated with steeper delay discounting rates; however, it is unknown whether substance co-use, particularly cannabis use, has an additive effect on discounting rates among heavy drinkers. Furthermore, it is unclear whether substance co-use and delay discounting are independently associated with AUD severity.<h4>Objectives</h4>The purpose of this study was to determine whether alcohol, tobacco, and cannabis co-use impacts delay discounting rates. ...[more]

PMID: 34652499

Similar Datasets

Project description:Background and aimsCannabis is commonly used among people who drink alcohol, but evidence suggests a nuanced relationship between alcohol consumption and cannabis use. In particular, among individuals undergoing alcohol treatment the impact of cannabis on alcohol intake may depend upon cannabis use frequency. We aimed to test the effects of within-day cannabis use on total drinks consumed and likelihood of binge drinking on a given day among all participants and compare these relationships between males and females and between individuals who reported infrequent and frequent cannabis use.DesignThis observational study is a substudy of a larger randomized controlled trial (RCT). Individuals were included from the RCT if they reported any cannabis use and were divided into groups based on cannabis use patterns. Alcohol use was compared within and between groups.SettingIndividuals were recruited from 2016 to 2020 from community and university settings in Denver and Boulder, CO, USA.ParticipantsOf the 182 individuals enrolled in the RCT, 96 cannabis-using subjects were included in these analyses.MeasurementsSubjects completed a time-line follow-back (TLFB) at baseline, 4, 8 (end of treatment) and 20 weeks. Daily data on alcohol and cannabis use from the TLFB at all time-points were analyzed.FindingsAcross the sample (n = 96), individuals drank approximately 29% fewer drinks [95% confidence interval (CI) = 18-39%, P < 0.001] and were 2.06 times (95% CI =1.37-3.08, P < 0.001) less likely to have a binge-drinking episode on days that cannabis was used compared with days that cannabis was not used. These patterns were observed in males, females and the infrequent and frequent cannabis use groups. Findings were inconclusive regarding differences in the association between cannabis use and alcohol outcomes when comparing males and females and when comparing infrequent and frequent cannabis use groups.ConclusionsHeavy drinkers engaged in treatment to reduce their alcohol consumption who also use cannabis appear to increase their cannabis use on days when they reduce their alcohol consumption.

Dataset Information

Additive roles of tobacco and cannabis co-use in relation to delay discounting in a sample of heavy drinkers.

Rationale

Objectives

Methods

Results

Conclusions

Publications

Additive roles of tobacco and cannabis co-use in relation to delay discounting in a sample of heavy drinkers.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets