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Group 3 Pulmonary Hypertension: From Bench to Bedside.


ABSTRACT: Pulmonary hypertension (PH) because of chronic lung disease is categorized as Group 3 PH in the most recent classification system. Prevalence of these diseases is increasing over time, creating a growing need for effective therapeutic options. Recent approval of the first pulmonary arterial hypertension therapy for the treatment of Group 3 PH related to interstitial lung disease represents an encouraging advancement. This review focuses on molecular mechanisms contributing to pulmonary vasculopathy in chronic hypoxia, the pathology and epidemiology of Group 3 PH, the right ventricular dysfunction observed in this population and clinical trial data that inform the use of pulmonary vasodilators in Group 3 PH.

SUBMITTER: Singh N 

PROVIDER: S-EPMC9060386 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Group 3 Pulmonary Hypertension: From Bench to Bedside.

Singh Navneet N   Dorfmüller Peter P   Shlobin Oksana A OA   Ventetuolo Corey E CE  

Circulation research 20220428 9


Pulmonary hypertension (PH) because of chronic lung disease is categorized as Group 3 PH in the most recent classification system. Prevalence of these diseases is increasing over time, creating a growing need for effective therapeutic options. Recent approval of the first pulmonary arterial hypertension therapy for the treatment of Group 3 PH related to interstitial lung disease represents an encouraging advancement. This review focuses on molecular mechanisms contributing to pulmonary vasculopa  ...[more]

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