Dataset Information

Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults.

ABSTRACT:

Background

HIV has been shown to increase the likelihood of oral HPV infection. In this study, we evaluated the risk of oral HPV in HIV infected patients compared with HIV-negative controls.

Methods

101 healthy adult volunteers (HIV-) and 245 adults living with HIV infection (HIV+) were recruited from 5 academic medical centers. Questionnaires and saliva samples were obtained every 3-8 months over a period of 2 years (2015-2017). DNA was isolated from the saliva samples and tested for 18 high- and low-risk genotypes.

Results

Oral HPV was detected in 23% of HIV + vs. 10% of HIV- participants (p < 0.0001). Men had a higher oral HPV prevalence than women (27% vs. 15% HIV+, p = 0.03, 16% vs. 5% HIV-, p = 0.01). Risk factors among HIV + participants included more lifetime deep kissing and oral sex partners, and history of AIDS. Persistent oral HPV was detected in 23% of HIV + vs. 5% of HIV- participants (p < 0.001). Among 8 HIV + participants with CD4 counts <200 cell/μL none had cleared their HPV infection during the study.

Conclusions

Risk of oral HPV infection and persistence was significantly higher in HIV + adults with a history of poorly controlled HIV, which may put them at increased risk of HPV-associated cancer.

SUBMITTER: Riddell J

PROVIDER: S-EPMC9062318 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults.

Riddell James J Brouwer Andrew F AF Walline Heather M HM Campredon Lora P LP Meza Rafael R Eisenberg Marisa C MC Andrus Emily C EC Delinger Rachel L RL Yost Monica L ML McCloskey Jodi K JK Thomas Trey B TB Huang Suiyuan S Ferris Robert L RL Shin Dong Moon DM Fakhry Carole C Ow Thomas T Li Daniel D Berlot Ashley A Carey Thomas E TE Schlecht Nicolas F NF

Tumour virus research 20220420

<h4>Background</h4>HIV has been shown to increase the likelihood of oral HPV infection. In this study, we evaluated the risk of oral HPV in HIV infected patients compared with HIV-negative controls.<h4>Methods</h4>101 healthy adult volunteers (HIV-) and 245 adults living with HIV infection (HIV+) were recruited from 5 academic medical centers. Questionnaires and saliva samples were obtained every 3-8 months over a period of 2 years (2015-2017). DNA was isolated from the saliva samples and tested ...[more]

PMID: 35460939

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Dataset Information

Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults.

Background

Methods

Results

Conclusions

Publications

Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults.

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