Ontology highlight
ABSTRACT:
SUBMITTER: Ton NNH
PROVIDER: S-EPMC9064357 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Ton Nhan N H NNH Dang Ha V HV Phan Nam T S NTS Nguyen Tung T TT
RSC advances 20190523 28
A Friedländer-based method for transition-metal free, aerobic synthesis of chromene-fused quinolinones is reported. The coupling of 4-hydrocoumarins and 2-aminobenzyl alcohols proceeds in the presence of acetic acid solvent and oxygen oxidant, affording 6<i>H</i>-chromeno[4,3-<i>b</i>]quinolin-6-ones in good to excellent yields. The reactions are tolerant of functionalities such as alkyl, methoxy, bromo, chloro, and <i>N</i>-heterocycle. Isosteric cyclic 1,3-diketones and 2-amino acetophenones a ...[more]