Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Continuous microfluidic fabrication of polypyrrole nanoparticles.

ABSTRACT: Polypyrrole (PPy) nanoparticles were synthesized successfully by oxidation polymerization in droplets by microfluidic system. The oxidizing agent ammonium persulfate was added at various molar ratios with respect to the monomer. The details of the procedure, droplet formation inside the channel and the effects of various factors are described. The method is a fast and continuous way for the synthesis of PPy. Products were characterized using Fourier-transform infrared spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, X-ray diffraction, thermal gravimetric analysis, cyclic voltammetry, electrochemical impedance spectroscopy and photoluminescence spectroscopy.

SUBMITTER: Effati E

PROVIDER: S-EPMC9064579 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Continuous microfluidic fabrication of polypyrrole nanoparticles.

Effati Elham E Pourabbas Behzad B Zakerhamidi Mohammad Sadegh MS

RSC advances 20190530 30

Polypyrrole (PPy) nanoparticles were synthesized successfully by oxidation polymerization in droplets by microfluidic system. The oxidizing agent ammonium persulfate was added at various molar ratios with respect to the monomer. The details of the procedure, droplet formation inside the channel and the effects of various factors are described. The method is a fast and continuous way for the synthesis of PPy. Products were characterized using Fourier-transform infrared spectroscopy, field emissio ...[more]

PMID: 35519887

Similar Datasets

Ex Situ Fabrication of Polypyrrole-Coated Core-Shell Nanoparticles for High-Performance Coin Cell Supercapacitor.

Project description:Silica-conducting polymer (SiO?-CP) has the advantages of high electrical conductivity, structural stability, and the facile formation of thin-film. This work deals with the preparation and optimization of polypyrrole (PPy)-encapsulated silica nanoparticles (SiO? NPs) using an ex situ method. The SiO?-PPy core-shell NPs prepared by the ex situ method are well dispersed in water and facilitate the mass production of thin-film electrodes with improved electrical and electrochemical performances using a simple solution process. As-prepared SiO?-PPy core-shell NPs with different particle sizes were applied to electrode materials for two-electrode supercapacitors based on coin cell batteries. It was confirmed that the areal capacitance (73.1 mF/cm²), volumetric capacitance (243.5 F/cm³), and cycling stability (88.9% after 5000 cycles) of the coin cell employing the ex situ core-shell was superior to that of the conventional core-shell (4.2 mF/cm², 14.2 mF/cm³, and 82.2%). Considering these facts, the ex situ method provides a facile way to produce highly-conductive thin-film electrodes with enhanced electrical and electrochemical properties for the coin cell supercapacitor application.

| S-EPMC6164064 | biostudies-literature

Microfluidic fabrication of lipid nanoparticles for the delivery of nucleic acids.

Project description:Gene therapy has emerged as a potential platform for treating several dreaded and rare diseases that would not have been possible with traditional therapies. Viral vectors have been widely explored as a key platform for gene therapy due to their ability to efficiently transport nucleic acid-based therapeutics into the cells. However, the lack of precision in their delivery has led to several off-target toxicities. As such, various strategies in the form of non-viral gene delivery vehicles have been explored and are currenlty employed in several therapies including the SARS-CoV-2 vaccine. In this review, we discuss the opportunities lipid nanoparticles (LNPs) present for efficient gene delivery. We also discuss various synthesis strategies via microfluidics for high throughput fabrication of non-viral gene delivery vehicles. We conclude with the recent applications and clinical trials of these vehicles for the delivery of different genetic materials such as CRISPR editors and RNA for different medical conditions ranging from cancer to rare diseases.

| S-EPMC9035142 | biostudies-literature

Photoacoustic Properties of Polypyrrole Nanoparticles.

Project description:Photoacoustic imaging, an emerging modality, provides supplemental information to ultrasound imaging. We investigated the properties of polypyrrole nanoparticles, which considerably enhance contrast in photoacoustic images, in relation to the synthesis procedure and to their size. We prepared polypyrrole nanoparticles by water-based redox precipitation polymerization in the presence of ammonium persulphate (ratio nPy:nOxi 1:0.5, 1:1, 1:2, 1:3, 1:5) or iron(III) chloride (nPy:nOxi 1:2.3) acting as an oxidant. To stabilize growing nanoparticles, non-ionic polyvinylpyrrolidone was used. The nanoparticles were characterized and tested as a photoacoustic contrast agent in vitro on an imaging platform combining ultrasound and photoacoustic imaging. High photoacoustic signals were obtained with lower ratios of the oxidant (nPy:nAPS ≥ 1:2), which corresponded to higher number of conjugated bonds in the polymer. The increasing portion of oxidized structures probably shifted the absorption spectra towards shorter wavelengths. A strong photoacoustic signal dependence on the nanoparticle size was revealed; the signal linearly increased with particle surface. Coated nanoparticles were also tested in vivo on a mouse model. To conclude, polypyrrole nanoparticles represent a promising contrast agent for photoacoustic imaging. Variations in the preparation result in varying photoacoustic properties related to their structure and allow to optimize the nanoparticles for in vivo imaging.

| S-EPMC8470055 | biostudies-literature

Microfluidic-Assisted Fabrication of Dual-Coated pH-Sensitive Mesoporous Silica Nanoparticles for Protein Delivery.

Project description:Microfluidics has become a popular method for constructing nanosystems in recent years, but it can also be used to coat other materials with polymeric layers. The polymeric coating may serve as a diffusion barrier against hydrophilic compounds, a responsive layer for controlled release, or a functional layer introduced to a nanocomposite for achieving the desired surface chemistry. In this study, mesoporous silica nanoparticles (MSNs) with enlarged pores were synthesized to achieve high protein loading combined with high protein retention within the MSN system with the aid of a microfluidic coating. Thus, MSNs were first coated with a cationic polyelectrolyte, poly (diallyldimethylammonium chloride) (PDDMA), and to potentially further control the protein release, a second coating of a pH-sensitive polymer (spermine-modified acetylated dextran, SpAcDEX) was deposited by a designed microfluidic device. The protective PDDMA layer was first formed under aqueous conditions, whereby the bioactivity of the protein could be maintained. The second coating polymer, SpAcDEX, was preferred to provide pH-sensitive protein release in the intracellular environment. The optimized formulation was effectively taken up by the cells along with the loaded protein cargo. This proof-of-concept study thus demonstrated that the use of microfluidic technologies for the design of protein delivery systems has great potential in terms of creating multicomponent systems and preserving protein stability.

| S-EPMC8946851 | biostudies-literature

Continuous Operation on Synthesis and Surface Modification of Rutile Nanoparticles in Designed Microfluidic Reactors.

Project description:Synthesis and surface modification of rutile nanoparticles (NPs) are two distinct processes. Conventionally, they should be conducted separately. In this work, synthesis and surface modification of rutile NPs are consecutively performed in a designed microfluidic system, thereby avoiding the pilot processes, giving a high controllability and low-energy consumption of the process, and the preparation process of the coated TiO2 is simplified effectively. Samples synthesized using different strategies are compared, and the results demonstrate that the sample prepared using the microfluidic method shows a smaller particle size (60 nm) and a narrower particle size distribution range than those synthesized using the other two methods. Rutile NPs are most commonly used in terms of suspensions, the stability of the suspensions consisting of the naked and coated samples are assessed in terms of turbidity, agglomeration size, and settlement rate. Response surface methodology is employed to quantify the effects of the factors on the stability of suspensions.

| S-EPMC7288598 | biostudies-literature

Electrically controlled release of insulin using polypyrrole nanoparticles.

Project description:Conducting polymers present an opportunity for developing programmable, adjustable, spatially, and temporally controllable drug delivery systems. While several small molecule drugs have been released from thin conductive polymeric films successfully, delivering large molecule therapeutics, such as polypeptides and nucleic acids, has remained a significant challenge. Poor drug loading (∼ng cm-2) of thin films coupled with film instability has, in many cases, made conducting polymer films refractory to clinical development. To address these limitations, we have utilized conductive polymer nanoparticulate backbones to controllably release insulin, a high molecular weight, clinically relevant polypeptide. We find that the interaction between insulin and the polymer scaffold can be described by a simple Langmuir-type adsorption model. By modifying the ratio of the amount of nanoparticles to the amount of insulin, we have obtained drug loading percentages estimated to be as high as 51 wt% percent. In vivo experiments in mice confirmed retained bioactivity of the released insulin after electrical stimulation.

| S-EPMC5215613 | biostudies-literature

Fabrication of nanochitosan incorporated polypyrrole/alginate conducting scaffold for neural tissue engineering.

Project description:The utilization of conductive polymers for fabrication of neural scaffolds have attracted much interest because of providing a microenvironment which can imitate nerve tissues. In this study, polypyrrole (PPy)-alginate (Alg) composites were prepared using different percentages of alginate and pyrrole by oxidative polymerization method using FeCl3 as an oxidant and electrical conductivity of composites were measured by four probe method. In addition, chitosan-based nanoparticles were synthesized by ionic gelation method and after characterization merged into PPy-Alg composite in order to fabricate a conductive, hydrophilic, processable and stable scaffold. Physiochemical characterization of nanochitosan/PPy-Alg scaffold such as electrical conductivity, porosity, swelling and degradation was investigated. Moreover, cytotoxicity and proliferation were examined by culturing OLN-93 neural and human dermal fibroblasts cells on the Nanochitosan/PPy-Alg scaffold. Due to the high conductivity, the film with ratio 2:10 (PPy-Alg) was recognized more suitable for fabrication of the final scaffold. Results from FT-IR and SEM, evaluation of porosity, swelling and degradation, as well as viability and proliferation of OLN-93 neural and fibroblast cells confirmed cytocompatiblity of the Nanochitosan/PPy-Alg scaffold. Based on the features of the constructed scaffold, Nanochitosan/PPy-Alg scaffold can be a proper candidate for neural tissue engineering.

| S-EPMC7744540 | biostudies-literature

Continuous Flow Microfluidic Bioparticle Concentrator.

Project description:Innovative microfluidic technology has enabled massively parallelized and extremely efficient biological and clinical assays. Many biological applications developed and executed with traditional bulk processing techniques have been translated and streamlined through microfluidic processing with the notable exception of sample volume reduction or centrifugation, one of the most widely utilized processes in the biological sciences. We utilize the high-speed phenomenon known as inertial focusing combined with hydraulic resistance controlled multiplexed micro-siphoning allowing for the continuous concentration of suspended cells into pre-determined volumes up to more than 400 times smaller than the input with a yield routinely above 95% at a throughput of 240 ml/hour. Highlighted applications are presented for how the technology can be successfully used for live animal imaging studies, in a system to increase the efficient use of small clinical samples, and finally, as a means of macro-to-micro interfacing allowing large samples to be directly coupled to a variety of powerful microfluidic technologies.

| S-EPMC4462155 | biostudies-literature

Microfluidic fabrication of cell adhesive chitosan microtubes.

Project description:Chitosan has been used as a scaffolding material in tissue engineering due to its mechanical properties and biocompatibility. With increased appreciation of the effect of micro- and nanoscale environments on cellular behavior, there is increased emphasis on generating microfabricated chitosan structures. Here we employed a microfluidic coaxial flow-focusing system to generate cell adhesive chitosan microtubes of controlled sizes by modifying the flow rates of a chitosan pre-polymer solution and phosphate buffered saline (PBS). The microtubes were extruded from a glass capillary with a 300 ?m inner diameter. After ionic crosslinking with sodium tripolyphosphate (TPP), fabricated microtubes had inner and outer diameter ranges of 70-150 ?m and 120-185 ?m. Computational simulation validated the controlled size of microtubes and cell attachment. To enhance cell adhesiveness on the microtubes, we mixed gelatin with the chitosan pre-polymer solution. During the fabrication of microtubes, fibroblasts suspended in core PBS flow adhered to the inner surface of chitosan-gelatin microtubes. To achieve physiological pH values, we adjusted pH values of chiotsan pre-polymer solution and TPP. In particular, we were able to improve cell viability to 92 % with pH values of 5.8 and 7.4 for chitosan and TPP solution respectively. Cell culturing for three days showed that the addition of the gelatin enhanced cell spreading and proliferation inside the chitosan-gelatin microtubes. The microfluidic fabrication method for ionically crosslinked chitosan microtubes at physiological pH can be compatible with a variety of cells and used as a versatile platform for microengineered tissue engineering.

| S-EPMC3651799 | biostudies-literature

Continuous Fabrication of Monodisperse Ceria-Zirconia-Yttria Composite Oxide Nanoparticles Using a Novel High-Shear Agitation Reactor.

Project description:Monodisperse ceria-zirconia nanoparticles have attracted much attention as potential high-performance catalysts. Acidic aqueous solutions are generally used for peptizing aggregated precipitates during the fabrication of disperse nanoparticles. However, the peptization process requires multiple hours of aging, which significantly decreases the production efficiency. Hence, various researchers have attempted to eliminate this stage altogether by performing a coprecipitation process under ambient conditions using common salts as the starting materials. In this work, we report a continuous and direct technique for the fabrication of monodisperse composite oxide nanoparticles via coprecipitation inside a novel high-shear agitation reactor without aging. Using this method, monodisperse ceria-zirconia-yttria composite oxide nanoparticles with diameters of 3 nm were successfully synthesized.

| S-EPMC6644578 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data