Ontology highlight
ABSTRACT:
SUBMITTER: Yu J
PROVIDER: S-EPMC9066105 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Yu Jun J Shen Cong C Lin Meng M Chen Xia X Dai Xiuliang X Li Zhiran Z Wu Yunhao Y Fu Yangbo Y Lv Jinxing J Huang Xiaoyan X Zheng Bo B Sun Fei F
International journal of biological sciences 20220404 7
The self-renewal of spermatogonial stem cells (SSCs) requires a special microenvironment and is strictly controlled. Previously, we identified BMI1 as a key regulator of spermatogenesis in a knock-out mouse model. However, the mechanisms by which BMI1 regulates SSC maintenance remain largely unknown. Herein, we show that BMI1 is essential for SSC maintenance. BMI1 directs the transcriptional repression of target genes by increasing H2AK119ub and reducing H3K4me3 in SSCs. Furthermore, BMI1 inhibi ...[more]