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N-Heterocyclic carbene copper catalyzed quinoline synthesis from 2-aminobenzyl alcohols and ketones using DMSO as an oxidant at room temperature.

ABSTRACT: A facile and practical process for the synthesis of quinolines through an N-heterocyclic carbene copper catalyzed indirect Friedländer reaction from 2-aminobenzyl alcohol and aryl ketones using DMSO as an oxidant at room temperature is reported. A series of quinolines were synthesized in acceptable yields.

SUBMITTER: Xu J

PROVIDER: S-EPMC9071191 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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N-Heterocyclic carbene copper catalyzed quinoline synthesis from 2-aminobenzyl alcohols and ketones using DMSO as an oxidant at room temperature.

Xu Jingxiu J Chen Qingmao Q Luo Zhigao Z Tang Xiaodong X Zhao Jinwu J

RSC advances 20190912 49

A facile and practical process for the synthesis of quinolines through an N-heterocyclic carbene copper catalyzed indirect Friedländer reaction from 2-aminobenzyl alcohol and aryl ketones using DMSO as an oxidant at room temperature is reported. A series of quinolines were synthesized in acceptable yields. ...[more]

PMID: 35529656

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