Dataset Information

Frailty Risk in Older Adults Associated With Long-Term Exposure to Ambient PM2.5 in 6 Middle-Income Countries.

ABSTRACT:

Background

A series of studies have explored the health effects of long-term exposure to ambient PM2.5 among older adults. However, few studies have investigated the adverse effect of long-term exposure to ambient PM2.5 on frailty, and the results are inconclusive. This study sought to investigate the associations between long-term exposure to ambient PM2.5 and frailty in 6 low- and middle-income countries.

Methods

We included an analytical sample of 34 138 individuals aged 50 and older from the Study on global AGEing and adult health Wave 1 (2007/2010). Air pollution estimates were generated using a standard methodology derived from Moderate Resolution Imaging Spectroradiometer observations and Multiangle Imaging Spectroradiometer instruments from the Terra satellite, along with simulations from the GEOS-Chem chemical transport model. A 3-level hierarchical logistic model was used to evaluate the association between frailty index and long-term PM2.5 exposure at 3 levels (individual, province, and country).

Results

In rural areas, each 10 μg/m3 increase in ambient PM2.5 was associated with a 30% increase in the odds of frailty (OR = 1.30, 95% CI: 1.21-1.39) after adjusting for various potential confounding factors. The gender-stratified analysis showed that the association seemed to be slightly stronger in men (OR = 1.31, 95% CI: 1.18-1.46) than in women (OR = 1.21, 95% CI: 1.07-1.36) in rural areas.

Conclusion

In a large sample of community-based older adults from 6 middle-income countries, we found evidence that long-term PM2.5 exposure was associated with frailty in rural areas.

SUBMITTER: Guo YF

PROVIDER: S-EPMC9071498 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Frailty Risk in Older Adults Associated With Long-Term Exposure to Ambient PM2.5 in 6 Middle-Income Countries.

Guo Yanfei F YF Ng Nawi N Kowal Paul P Lin Hualiang H Ruan Ye Y Shi Yan Y Wu Fan F

The journals of gerontology. Series A, Biological sciences and medical sciences 20220501 5

<h4>Background</h4>A series of studies have explored the health effects of long-term exposure to ambient PM2.5 among older adults. However, few studies have investigated the adverse effect of long-term exposure to ambient PM2.5 on frailty, and the results are inconclusive. This study sought to investigate the associations between long-term exposure to ambient PM2.5 and frailty in 6 low- and middle-income countries.<h4>Methods</h4>We included an analytical sample of 34 138 individuals aged 50 and ...[more]

PMID: 35134914

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Project description:Increasing global temperatures due to climate change have raised serious concerns regarding its potential impact on health outcomes. Pregnant women and their fetuses are among the most vulnerable groups being affected by these dramatic changes resulting in adverse outcomes for both the mother and the developing fetus. Evidence regarding heat-related pregnancy adversities in high-income countries is conclusive, however, such evidence is rare in low- and middle-income countries (LMICs). This review was conducted to bridge the knowledge gap by providing evidence-based insights into the specific repercussions of high heat exposures during pregnancy and its effect on birth outcomes in LMICs. A systematic review was conducted to assess the impact of high environmental or ambient temperatures on pregnancy outcomes (abortion, stillbirth, preterm birth, and low birthweight (LBW)) in LMICs. Electronic searches were conducted on MEDLINE, Embase, CINAHL, Web of Science, and Scopus. Observational studies published between 2010 and 2023 were included in the review. Screening of studies was done using Covidence software, data was extracted on Excel sheets and quality assessment was done using the National Institutes of Health's National Heart, Lung, and Blood Institute tool. We included 11 studies. Four of six studies that included preterm births showed an association between heat and preterm births. Four of five studies reported an association between heat exposure and LBW. Three of four studies on stillbirths showed a significant association between heat exposure and stillbirths. One of the two studies that reported spontaneous abortion revealed a significant association of heat with abortion. Meta-analysis could not be performed due to the lack of homogeneity in defining heat exposure. Amongst the included studies, seven were categorized as "good" and four were categorized as "fair" on methodological quality. This study concluded that ambient temperature and heat exposure during pregnancy can impact birth outcomes such as preterm births, LBWs, abortions, and stillbirths in LMICs. Urgent action is imperative on both national and global scales to facilitate a comprehensive and definitive assessment of heat exposure in LMICs, enabling a deeper understanding of its repercussions on pregnant women. Longitudinal studies are paramount for confirming these associations and devising targeted interventions and strategies aimed at enhancing maternal and child health within LMIC contexts. Registration: PROSPERO ID: CRD42023449173.

Dataset Information

Frailty Risk in Older Adults Associated With Long-Term Exposure to Ambient PM2.5 in 6 Middle-Income Countries.

Background

Methods

Results

Conclusion

Publications

Frailty Risk in Older Adults Associated With Long-Term Exposure to Ambient PM2.5 in 6 Middle-Income Countries.

Similar Datasets

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