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Palladium-catalyzed oxidative cross-coupling for the synthesis of α-amino ketones.

ABSTRACT: A novel oxidative cross-coupling reaction for the synthesis of α-aryl α-amino ketones in the presence of palladium catalysts using T⁺BF₄ ^- as an oxidant has been developed. This transformation was achieved by direct C-H oxidation of α-aminocarbonyl compounds and arylation. The mild reaction has a broad reaction scope and gives desired α-aryl α-amino ketones in moderate to excellent yields.

SUBMITTER: Wei XH

PROVIDER: S-EPMC9072988 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Palladium-catalyzed oxidative cross-coupling for the synthesis of α-amino ketones.

Wei Xiao-Hong XH Li Zhen-Hua ZH Zhao Lian-Biao LB Zhang Ping P Zhou Han-Cheng HC Wang Yan-Bin YB

RSC advances 20191009 55

A novel oxidative cross-coupling reaction for the synthesis of α-aryl α-amino ketones in the presence of palladium catalysts using T+BF4 - as an oxidant has been developed. This transformation was achieved by direct C-H oxidation of α-aminocarbonyl compounds and arylation. The mild reaction has a broad reaction scope and gives desired α-aryl α-amino ketones in moderate to excellent yields. ...[more]

PMID: 35530775

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