Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC9073254 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Li Jiagen J Li Xinming X Xie Pengwei P Liu Peng P
Journal of pharmaceutical analysis 20210309 1
A mixed drug self-delivery system (DSDS) with high drug content (>50%) was developed to regulate pH-triggered drug release, based on two doxorubicin (DOX)-DOX dimmers: D-DOX<sub>ADH</sub> and D-DOX<sub>car</sub> conjugated with acid-labile dynamic covalent bonds (hydrazone and carbamate, respectively) and stabilized with PEGylated D-DOX<sub>ADH</sub> (D-DOX<sub>ADH</sub>-PEG). Owing to the different stability of the dynamic covalent bonds in the two dimers and the noncovalent interaction between ...[more]