Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging.
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ABSTRACT:
SUBMITTER: Thakare V
PROVIDER: S-EPMC9073358 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging.
Thakare Vivek V Tran Vu-Long VL Natuzzi Marco M Thomas Eloïse E Moreau Mathieu M Romieu Anthony A Collin Bertrand B Courteau Alan A Vrigneaud Jean-Marc JM Louis Cédric C Roux Stéphane S Boschetti Frédéric F Tillement Olivier O Lux François F Denat Franck F
RSC advances 20190809 43
A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles <i>via</i> a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with <sup>64</sup>Cu, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging. ...[more]
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