Dataset Information

A Zn(ii) metal-organic framework based on bimetallic paddle wheels as a luminescence indicator for carcinogenic organic pollutants: phthalate esters.

ABSTRACT: Based on the multifunctional ligand 3-(1H-1,2,4-triazol-1-yl)isophthalic acid (H₂TIA), a three-dimensional coordination polymer, namely {[Zn(TIA)]·DMA} _n (Zn-1) was synthesized solvothermally. Single-crystal X-ray diffraction analyses confirmed that Zn-1 is a 3D framework composed of binuclear Zn₂ paddle wheels with one-dimensional channels long the a direction. Further topological analyses revealed that MOF Zn-1 existed as a (3,6)-connected rtl binodal net {4·6²}²{4²·6¹⁰·8³}. Furthermore, the luminescence explorations indicate that complex Zn-1 is the first MOF for luminescent probing of phthalate esters (carcinogenic organic pollutants) with a high quenching-efficiency constant and low fluorescence-detection limit.

SUBMITTER: Wu MZ

PROVIDER: S-EPMC9075595 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

A Zn(ii) metal-organic framework based on bimetallic paddle wheels as a luminescence indicator for carcinogenic organic pollutants: phthalate esters.

Wu Ming Ze MZ Ma Zhi Long ZL Shi Jian Yun JY Tian Li L

RSC advances 20191113 63

Based on the multifunctional ligand 3-(1H-1,2,4-triazol-1-yl)isophthalic acid (H2TIA), a three-dimensional coordination polymer, namely {[Zn(TIA)]·DMA} n (Zn-1) was synthesized solvothermally. Single-crystal X-ray diffraction analyses confirmed that Zn-1 is a 3D framework composed of binuclear Zn2 paddle wheels with one-dimensional channels long the a direction. Further topological analyses revealed that MOF Zn-1 existed as a (3,6)-connected ...[more]

PMID: 35539047

Similar Datasets

Project description:Phthalates are chemicals that are extensively used in the manufacturing of cosmetic products. The occurrence of phthalate esters in personal care products may pose adverse effects on consumers' health. In this work, a simple, fast and reliable GC-MS method was developed and validated for concurrent determination of phthalate esters in fragrances. Simple procedures were employed for sample preparation and clean up. The recoveries achieved were in the range of 94.9% to 105.6% with RSD ≤ 4.06. The detection limits were in the range of 0.0010 to 0.0021 µg/mL. The GC-MS method was utilized to investigate the occurrence of phthalate esters in different brands of perfumes sold in the Saudi Arabian market. Diethyl phthalate was detected in all analyzed samples, with a maximum concentration of 5766 µg/mL, and di (2-ethylhexyl) phthalate was detected in the majority of the analyzed samples (95%), with a mean concentration of 55.9 µg/mL and a highest concentration of 377.7 µg/mL. Additionally, the exposure to phthalate esters due to the consumption of perfumes was investigated among the adult Saudi population for the first time. It was found that the systemic exposure dose, measured at mean concentrations, ranged from 4.59 × 10-4 to 4.29 × 10-2 (mg/kg/day) and from 5.00 × 10-4 to 4.68 × 10-2 (mg/kg/day) for male and female users, respectively. Moreover, the non-carcinogenic risk of the investigated phthalate esters and the carcinogenic risk of DEHP were also evaluated. The non-carcinogenic risk values of the detected phthalate esters were greater than 100, which indicates that exposure to these phthalate esters is unlikely to produce non-carcinogenic health effects to consumers. However, at maximum DEHP concentrations, the carcinogenic risk values were 5.49 × 10-5 for male users and 5.98 × 10-5 for female users, which indicates the possibility of DEHP to pose a carcinogenic health effect if present at high levels. Regular monitoring of undeclared chemicals such as phthalate esters in personal care products marketed in Saudi Arabia is extremely important to ensure consumers' safety. To the best of the authors' knowledge, this is the first study to assess the health risk associated with consumption of perfumes in Saudi Arabia.

Project description:Di(ethylhexyl) phthalate (DEHP) is a ubiquitous environmental contaminant to which humans are exposed via multiple routes. Human health risk assessments for this substance have recently been updated, focusing on reproductive toxicity, including DEHP, in the list of chemicals classified as carcinogenic, mutagenic, or toxic to reproduction (CMR). Moreover, DEHP has also been defined as probably and possibly carcinogenic to humans based on its carcinogenicity in rodents. However, the mechanism of action of DEHP and its relevance in humans remain unclear. Rodent data suggests that DEHP induces cancer through non-genotoxic mechanisms related to multiple molecular signals, including PPARα activation, perturbation of fatty acid metabolism, induction of cell proliferation, decreased apoptosis, production of reactive oxygen species, and oxidative stress. According to the DEHP toxicological dataset, several in vitro cell transformation assays have been performed using different protocols and cellular models to produce different results. This study aimed to evaluate the carcinogenic potential of DEHP by using the A31-1-1 BALB/c-3T3 cell line in a standard cell transformation assay. Additionally, transcriptomic analysis was performed to explore the molecular responses and identify the affected toxicological pathways. Although DEHP treatment did not induce transformation in BALB/c-3T3 cells, the transcriptomic results revealed significant modulation of several pathways associated with DEHP metabolism, tissue-specific functions related to systemic metabolism, and basal cellular signaling with pleiotropic outcomes. Among these signaling pathways, modulation of cell-regulating signaling pathways, such as Notch, Wnt, and TGF-β, can be highlighted. More specific modulation of such genes and pathways with double functions in metabolism and neurophysiology underlies the well-known crosstalk that may be crucial for the mechanism of action of DEHP. Our findings offer evidence to support the notion that these models are effective in minimizing the use of animal testing for toxicity assessment.

Dataset Information

A Zn(ii) metal-organic framework based on bimetallic paddle wheels as a luminescence indicator for carcinogenic organic pollutants: phthalate esters.

Publications

A Zn(ii) metal-organic framework based on bimetallic paddle wheels as a luminescence indicator for carcinogenic organic pollutants: phthalate esters.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets