Ontology highlight
ABSTRACT:
SUBMITTER: Bellais S
PROVIDER: S-EPMC90766 | biostudies-literature | 2001 Oct
REPOSITORIES: biostudies-literature
Bellais S S Poirel L L Fortineau N N Decousser J W JW Nordmann P P
Antimicrobial agents and chemotherapy 20011001 10
From whole-cell DNA of a clinical isolate of the enterobacterial species Rahnella aquatilis, a beta-lactamase gene was cloned that encoded a chromosomally encoded Ambler class A enzyme, RAHN-1. RAHN-1, with a pI of 7.2, shares 76, 73, and 71% amino acid identity with the extended-spectrum beta-lactamase of chromosomal origin from Serratia fonticola and with the plasmid-mediated beta-lactamases CTX-M-2 and CTX-M-1, respectively. The hydrolysis spectrum of the clavulanic acid-inhibited RAHN-1 was ...[more]