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Metal-free C-H arylation of imidazoheterocycles with aryl hydrazines.

ABSTRACT: A simple and efficient metal-free arylation of imidazo[1,2-a]pyridines at the C-3 position with arylhydrazine has been achieved at room temperature under ambient air conditions. Various 2,3-disubstituted imidazopyridines and imidazothiazoles were synthesized with high yields. The present methodology demonstrates the usefulness of commercially available aryl hydrazine as an arylating agent.

SUBMITTER: Jana S

PROVIDER: S-EPMC9079221 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Metal-free C-H arylation of imidazoheterocycles with aryl hydrazines.

Jana Sourav S Samanta Sadhanendu S Bagdi Avik K AK Shirinian Valerii Z VZ Hajra Alakananda A

RSC advances 20180301 22

A simple and efficient metal-free arylation of imidazo[1,2-<i>a</i>]pyridines at the C-3 position with arylhydrazine has been achieved at room temperature under ambient air conditions. Various 2,3-disubstituted imidazopyridines and imidazothiazoles were synthesized with high yields. The present methodology demonstrates the usefulness of commercially available aryl hydrazine as an arylating agent. ...[more]

PMID: 35539413

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