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One-pot synthesis of chiral alcohols from alkynes by CF₃SO₃H/ruthenium tandem catalysis.

ABSTRACT: A practical one-pot synthesis of chiral alcohols from readily available alkynes via tandem catalysis by the combination of CF₃SO₃H and a fluorinated chiral diamine Ru(ii) complex in aqueous CF₃CH₂OH is described. Very interestingly, the combination of fluorinated catalysts and solvent exhibits a positive fluorine effect on the reactivity and enantioselectivity. A range of chiral alcohols with wide functional group tolerance was obtained in high yield and excellent stereoselectivity under simple and mild conditions.

SUBMITTER: Liu H

PROVIDER: S-EPMC9079948 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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One-pot synthesis of chiral alcohols from alkynes by CF3SO3H/ruthenium tandem catalysis.

Liu Huan H Liu Sensheng S Zhou Haifeng H Liu Qixing Q Wang Chunqin C

RSC advances 20180419 27

A practical one-pot synthesis of chiral alcohols from readily available alkynes via tandem catalysis by the combination of CF3SO3H and a fluorinated chiral diamine Ru(ii) complex in aqueous CF3CH2OH is described. Very interestingly, the combination of fluorinated catalysts and solvent exhibits a positive fluorine effect on the reactivity and enantioselectivity. A range of chiral alcohols with wide functional group tolerance was obtained in high ...[more]

PMID: 35541341

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