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Copper-catalyzed tandem reaction of 2-alkynylanilines with benzoquinones: efficient access to 3-indolylquinones.

ABSTRACT: A simple, mild, catalytic and efficient method for the straightforward synthesis of an interesting class of 2-aryl/alkyl-substituted-3-indolyl quinones in good to high yields is reported for the first time. This atom-efficient method proceeds via copper-catalyzed one-pot sequential intramolecular hydroamination (C-N bond formation) of 2-alkynylanilines followed by oxidative C-C coupling with benzoquinones.

SUBMITTER: Jillella R

PROVIDER: S-EPMC9081399 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Copper-catalyzed tandem reaction of 2-alkynylanilines with benzoquinones: efficient access to 3-indolylquinones.

Jillella Raveendra R Oh Chang Ho CH

RSC advances 20180615 39

A simple, mild, catalytic and efficient method for the straightforward synthesis of an interesting class of 2-aryl/alkyl-substituted-3-indolyl quinones in good to high yields is reported for the first time. This atom-efficient method proceeds <i>via</i> copper-catalyzed one-pot sequential intramolecular hydroamination (C-N bond formation) of 2-alkynylanilines followed by oxidative C-C coupling with benzoquinones. ...[more]

PMID: 35541709

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