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Preparation of triangular silver nanoplates by silver seeds capped with citrate-CTA.

ABSTRACT: Due to the competitive growth on the crystal face of seed, it is always difficult to control the morphology of the formation of nanoparticles precisely by a seed-mediated growth method. Herein, we provided a simple but effective technique to synthesize silver nanotriangles using a new silver seed that is capped with citrate-CTA⁺ (CTA⁺ is cetyltrimethyl ammonium cation). Compared to the preparation of silver nanoparticles (AgNPs) by a conventional seed-mediated method, in this paper, we presented a growth technique with two distinct innovative changes. First, the concentrations of CTAB that we added in silver seed collosol have a significant impact on the size distribution, and silver nanotriangles, nanorods, and nanospheres could be obtained by adjusting the CTAB concentration. Second, the seed prepared by our method has a longer use time, and silver nanotriangles, nanospheres, and nanorods could be prepared by adjusting the aged time of the seed colloid. We have also shown a simple way to control the morphology of silver nanoparticles in almost the same reactive medium by varying the NaOH concentration. Using the new silver seed capped with citrate-CTA⁺, we obtained triangular silver nanoparticles with relatively high regularity. Based on the limited experimental results and IR analysis, a possible mechanism was preliminarily proposed to explain the formation of the seed and the truncated triangular AgNPs.

SUBMITTER: Zhong Y

PROVIDER: S-EPMC9084414 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Preparation of triangular silver nanoplates by silver seeds capped with citrate-CTA.

Zhong Yuanzhi Y Liang Guorun G Jin Wenxiu W Jian Zhichao Z Wu Zhixiong Z Chen Qingyuan Q Cai Yuchun Y Zhang Wanzhong W

RSC advances 20180814 51

Due to the competitive growth on the crystal face of seed, it is always difficult to control the morphology of the formation of nanoparticles precisely by a seed-mediated growth method. Herein, we provided a simple but effective technique to synthesize silver nanotriangles using a new silver seed that is capped with citrate-CTA<sup>+</sup> (CTA<sup>+</sup> is cetyltrimethyl ammonium cation). Compared to the preparation of silver nanoparticles (AgNPs) by a conventional seed-mediated method, in th ...[more]

PMID: 35547977

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Project description:BackgroundIn recent years, silver nanoparticles (AgNPs) have gradually been widely used, especially in the field of anticancer medicine. Ovarian cancer (OC) is the gynaecological malignancy with the highest mortality rate, and the current treatment is still based on surgery, chemotherapy and postoperative targeted therapy. Therefore, the development of safe and effective nanoparticles for targeted therapy of OC is very important. This study aimed to prepare a new type of triangular silver nanoparticles (tAgNPs) and evaluate the anticancer properties for OC in vitro and in vivo.MethodsThe tAgNPs were chemically synthesized and characterized using scanning electron microscopy (SEM), ultraviolet (UV) spectrophotometry and other techniques. By performing cell-based tests, such as cell counting kit-8 (CCK-8), plate colony formation, cell apoptosis, reactive oxygen species (ROS), and western blot (WB) assays, the inhibitory effects and related mechanisms of tAgNPs on OC cells were analysed.The anticancer effect of tAgNPs in vivo was verified by a SKOV3 tumor-bearing mouse model.ResultsFive types of tAgNPs with different colours were successfully synthesized, with a particle size of 25-50 nm and a good dispersion. The results of in vitro experiments showed that tAgNPs treatment reduced the viability and proliferation of SKOV3 cells, arrested the cell cycle in G0/G1 phase, inhibited the expression levels of proliferation-related factors and cyclins, and promoted cell apoptosis by producing ROS and increasing caspase-3 activity. Consistent with the results of in vitro experiments, in vivo animal experiments also showed that tAgNPs significantly inhibited the proliferation of ovarian cancer. More importantly, no obvious toxic and side effects were observed.ConclusionsIn this study, a novel triangular AgNPs was successfully prepared. tAgNPs are very stable, significantly inhibit the proliferation of OC cells and tumour growth in tumour-bearing mice, providing a promising nanotargeted therapy for OC.

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Preparation of triangular silver nanoplates by silver seeds capped with citrate-CTA.

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Preparation of triangular silver nanoplates by silver seeds capped with citrate-CTA.

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