Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial.
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SUBMITTER: Munro APS
PROVIDER: S-EPMC9084623 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
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Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial.
Munro Alasdair P S APS Feng Shuo S Janani Leila L Cornelius Victoria V Aley Parvinder K PK Babbage Gavin G Baxter David D Bula Marcin M Cathie Katrina K Chatterjee Krishna K Dodd Kate K Enever Yvanne Y Qureshi Ehsaan E Goodman Anna L AL Green Christopher A CA Harndahl Linda L Haughney John J Hicks Alexander A van der Klaauw Agatha A AA Kanji Nasir N Libri Vincenzo V Llewelyn Martin J MJ McGregor Alastair C AC Maallah Mina M Minassian Angela M AM Moore Patrick P Mughal Mehmood M Mujadidi Yama F YF Holliday Kyra K Osanlou Orod O Osanlou Rostam R Owens Daniel R DR Pacurar Mihaela M Palfreeman Adrian A Pan Daniel D Rampling Tommy T Regan Karen K Saich Stephen S Bawa Tanveer T Saralaya Dinesh D Sharma Sunil S Sheridan Ray R Thomson Emma C EC Todd Shirley S Twelves Chris C Read Robert C RC Charlton Sue S Hallis Bassam B Ramsay Mary M Andrews Nick N Lambe Teresa T Nguyen-Van-Tam Jonathan S JS Snape Matthew D MD Liu Xinxue X Faust Saul N SN
The Lancet. Infectious diseases 20220509 8
<h4>Background</h4>Some high-income countries have deployed fourth doses of COVID-19 vaccines, but the clinical need, effectiveness, timing, and dose of a fourth dose remain uncertain. We aimed to investigate the safety, reactogenicity, and immunogenicity of fourth-dose boosters against COVID-19.<h4>Methods</h4>The COV-BOOST trial is a multicentre, blinded, phase 2, randomised controlled trial of seven COVID-19 vaccines given as third-dose boosters at 18 sites in the UK. This sub-study enrolled ...[more]
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